Brkic Marjana, Balusu Sriram, Libert Claude, Vandenbroucke Roosmarijn E
Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium ; Department of Neurobiology, Institute for Biological Research, University of Belgrade, 11060 Belgrade, Serbia.
Inflammation Research Center, VIB, 9052 Ghent, Belgium ; Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium.
Mediators Inflamm. 2015;2015:620581. doi: 10.1155/2015/620581. Epub 2015 Oct 11.
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases. Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration. Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions. MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies. Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases. Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and multiple sclerosis (MS). We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.
神经退行性变是神经元细胞的慢性进行性丧失，导致中枢神经系统（CNS）功能恶化。研究表明，在各种神经退行性疾病中，神经炎症先于神经退行性变出现。基质金属蛋白酶（MMPs）是一个含锌内肽酶的蛋白质家族，在（神经）炎症中起重要作用，可能与神经退行性变有关。尽管MMPs对机体的生理发育和功能不可或缺，但由于它们在各种病理条件下也会造成实质性损害的能力，它们常被称为双刃剑。MMP活性受到严格控制，其失调会导致多种病理状况。研究它们作为治疗靶点的潜在用途需要更好地了解它们对神经退行性疾病发展的作用。在此，我们综述MMPs及其在神经退行性疾病中的作用：阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）、亨廷顿舞蹈病（HD）和多发性硬化症（MS）。我们还讨论了MMP抑制作为治疗神经退行性疾病的一种可能治疗策略。
