Huang Yanhua, Li YeE, Chen Jian, Zhou Hongxing, Tan Sheng
Department of Neurology, Zhujiang Hospital of Southern Medical University , Guangzhou , China.
Department of Neurology, Dalang Hospital , Dongguan , China.
Front Hum Neurosci. 2015 Oct 19;9:586. doi: 10.3389/fnhum.2015.00586. eCollection 2015.
Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation, and integration of NSCs. Electrical stimulation (ES) may be a selective non-drug approach for mobilizing NSCs in the central nervous system. This technique is suitable for clinical application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair.
研究人员热衷于关注神经干细胞（NSC）疗法在包括中风、神经退行性疾病、脊髓损伤和抑郁症在内的多种疾病中的应用。尽管大量证据表明，在动物模型中，神经行为的改善可能得益于神经干细胞支持的再生，但内源性和移植的神经干细胞的应用方法受到神经干细胞迁移、增殖、成熟和整合等障碍的阻碍。电刺激（ES）可能是一种在中枢神经系统中动员神经干细胞的选择性非药物方法。这项技术适用于临床应用，因为它已得到充分证实，且其潜在并发症是可控的。在此，我们全面综述了不同电信号在体外和体内调节神经干细胞生物学方面新出现的积极作用，以及基于生物材料和化学物质对神经干细胞的刺激。未来，电刺激与干细胞疗法或其他信号相结合可能成为促进脑修复的一种方法。
