出生季节与成年期维生素 D 浓度。
Birth season and vitamin D concentration in adulthood.
机构信息
Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy.
出版信息
Ann Transl Med. 2015 Sep;3(16):231. doi: 10.3978/j.issn.2305-5839.2015.09.30.
BACKGROUND
Recent evidences suggest that the season of birth may influence human development and vulnerability to develop certain diseases.
METHODS
A retrospective analysis was hence carried out in the laboratory information system of the University Hospital of Parma (North-West Italy), to retrieve values of total serum vitamin D (25-hydroxyvitamin D) measured in a the whole cohort of unselected outpatients age 18 years and older referred for routine health check-up during January to December 2014. Vitamin D was then stratified according to birth season.
RESULTS
The study population consisted in 11,150 unselected Italian residents (median age 62 years; 8,592 women and 2,558 men). Serum vitamin D values were found to be significantly lower in subjects born in winter than in those born in spring and summer. More specifically, winter season birth was associated with 11% increased risk of developing vitamin D deficiency later in life compared to spring birth. Daily sunlight hours at birth independently predicted vitamin D concentration in adulthood.
CONCLUSIONS
The results of this large, cross-sectional retrospective investigation attest that subjects born in winter have a total vitamin D concentration in adulthood that is significantly lower than those born in seasons with longer daylight periods.
背景
最近的证据表明，出生季节可能会影响人类的发育和易患某些疾病的脆弱性。
方法
因此，在意大利西北部帕尔马大学医院的实验室信息系统中进行了回顾性分析，以检索 2014 年 1 月至 12 月期间因常规健康检查而就诊的所有未选择的 18 岁及以上门诊患者的血清总维生素 D（25-羟基维生素 D）值。然后根据出生季节对维生素 D 进行分层。
结果
研究人群由 11150 名未选择的意大利居民组成（中位数年龄为 62 岁；8592 名女性和 2558 名男性）。与春季出生的人群相比，冬季出生的人群血清维生素 D 值明显较低。具体而言，与春季出生相比，冬季出生的人群在以后的生活中维生素 D 缺乏的风险增加了 11%。出生时的每日阳光照射时间独立预测成年后的维生素 D 浓度。
结论
这项大规模、横断面回顾性调查的结果证明，冬季出生的人群在成年期的总维生素 D 浓度明显低于那些在日光时间较长的季节出生的人群。
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