Kruchinina A D, Gengin M T
Penza State University, Penza, Russia.
Biomed Khim. 2015 Sep-Oct;61(5):657-60. doi: 10.18097/PBMC20156105657.
Depression is one of the most common mental disorders, but its etiology is not completely understood. It is assumed that peptidergic system components are involved in the formation of this pathology. Neuropeptides play an important role in the regulation of mental and emotional states. Сarboxypeptidase E is a key enzyme of peptide processing; it regulates neuropeptide levels in the various structures of the nervous system. We have studied effects of a single dose of reboxetine on the activity of carboxypeptidase E in various brain regions and the adrenal glands of rats. The reboxetine injection decreased carboxypeptidase E activity in the pituitary gland (12 h after injection), in the pituitary gland, the quadrigeminal bodies, the medulla oblongata, the hypothalamus, the hippocampus and the amygdala (24 h after injection), in the pituitary gland and striatum (72 h after injection). The enzyme activity in adrenal glands remained basically unchanged. Apparently, the decrease of carboxypeptidase E activity may influence the level of regulatory peptides involved in the pathogenesis of depression.
抑郁症是最常见的精神障碍之一，但其病因尚未完全明确。据推测，肽能系统成分参与了这种病理状态的形成。神经肽在精神和情绪状态的调节中起着重要作用。羧肽酶E是肽加工的关键酶；它调节神经系统各个结构中的神经肽水平。我们研究了单剂量瑞波西汀对大鼠不同脑区及肾上腺中羧肽酶E活性的影响。注射瑞波西汀后，垂体中羧肽酶E活性在注射后12小时降低，在垂体、四叠体、延髓、下丘脑、海马和杏仁核中在注射后24小时降低，在垂体和纹状体中在注射后72小时降低。肾上腺中的酶活性基本保持不变。显然，羧肽酶E活性的降低可能会影响参与抑郁症发病机制的调节肽水平。
