[Activity of soluble and membrane-bound forms of carboxypeptidase H in regions of the rat brain in emotional stress].

Carboxypeptidase H activity in the brain of rats with different resistance to emotional stress was shown to change differently. The enzyme activity during stress in hypophysis was higher in predisposed rats but in striatum and hypothalamus it was lower in the animals stable to the stress. The activity of soluble and membrane bound enzyme in hypophysis during the emotional stress was changed in different direction but in striatum and hypothalamus the activity of both forms of the enzyme was changed equally. The activity of a soluble form was changed larger than in membrane-bound one. Differences of functions of soluble and membrane-bound forms and their participation in emotional stress development in rats with different tolerance to stress are discussed.