Veronese Nicola, Maggi Stefania, Noale Marianna, De Rui Marina, Bolzetta Francesco, Zambon Sabina, Corti Maria Chiara, Sartori Leonardo, Musacchio Estella, Baggio Giovannella, Perissinotto Egle, Crepaldi Gaetano, Manzato Enzo, Sergi Giuseppe
1 Department of Medicine (DIMED), Geriatrics Division, University of Padova , Italy .
2 National Research Council, Neuroscience Institute , Aging Branch, Padova, Italy .
Rejuvenation Res. 2015 Dec;18(6):543-53. doi: 10.1089/rej.2015.1671. Epub 2015 Nov 5.
Recent work has shown that low 25-hydroxyvitamin D (25OHD) levels are associated with the presence of osteoarthritis (OA), but these studies focused on radiographical changes of OA, investigated only one joint, and did not consider the association with OA-related pain. In this study, we aimed to examine the relationship between 25OHD levels and any presence of OA and pain in a cohort of older people. This study was part of the Progetto Veneto Anziani (Pro.V.A), a population-based cohort study in older people. In this cross-sectional work, we considered 2756 subjects (1102 males and 1654 females) with a mean age of 74.2 ± 7.1 years. OA and OA-related pain were defined using a standardized algorithm investigating disease history, medical documentation, symptoms, and physical examination of the joints. On logistic regression analysis, taking those in the highest 25OHD quartile for reference, those in the lowest quartile had significantly higher odds of OA involving the hands (odds ratio [OR] = 1.26, 95% confidence interval [CI] 1.15-1.38 in the sample as whole; 1.36, 95% CI 1.15-1.60 in men and 1.22, 95% CI 1.09-1.37 in women), and pain (OR = 1.18, 95% CI 1.06-1.32 in the sample as whole; 1.52, 95% CI 1.21-1.90 in men and 1.15, 95% CI 1.03-1.29 in women). Similar results were found for the hip. For the knee, low 25OHD levels were associated with the presence of OA in the sample as a whole, and in women, and with the presence of pain in the sample as a whole. In conclusion, low 25OHD levels are associated with the presence of OA and with OA-related pain, particularly when the hand and hip are involved.
近期研究表明，低水平的25-羟基维生素D（25OHD）与骨关节炎（OA）的存在有关，但这些研究聚焦于OA的影像学变化，仅对一个关节进行了调查，且未考虑与OA相关疼痛的关联。在本研究中，我们旨在调查一组老年人中25OHD水平与OA及疼痛之间的关系。本研究是威尼托老年人项目（Pro.V.A）的一部分，这是一项针对老年人的基于人群的队列研究。在这项横断面研究中，我们纳入了2756名受试者（1102名男性和1654名女性），平均年龄为74.2±7.1岁。OA及与OA相关的疼痛通过一种标准化算法进行定义，该算法调查疾病史、医疗记录、症状以及关节的体格检查。在逻辑回归分析中，以25OHD最高四分位数的人群作为参照，最低四分位数的人群手部患OA的几率显著更高（在整个样本中，比值比[OR]=1.26, 95%置信区间[CI] 1.15 - 1.38；男性为1.36, 95% CI 1.15 - 1.60，女性为1.22, 95% CI 1.09 - 1.37），且疼痛几率也更高（在整个样本中，OR = 1.18, 95% CI 1.06 - 1.32；男性为1.52, 95% CI 1.21 - 1.90，女性为1.15, 95% CI 1.03 - 1.29）。髋关节也有类似结果。对于膝关节，低25OHD水平在整个样本以及女性中与OA的存在相关，在整个样本中与疼痛的存在相关。总之，低25OHD水平与OA的存在以及与OA相关的疼痛有关，尤其是在手和髋关节受累时。
