Morgado Sergio Mascarenhas, da Fonseca Erica Lourenço, Vicente Ana Carolina Paulo
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 2025 Feb 3;120:e240159. doi: 10.1590/0074-02760240159. eCollection 2025.
Non-O1 and non-O139 Vibrio cholerae (NOVC) that cause bacteraemia have attracted the attention of the public health community around the world, mainly due to the prospect of outbreaks and the way to treat such infections.
To identify V. cholerae lineages and their antibiotic resistance and virulence factors associated with bacteraemia.
Vibrio cholerae genomes associated with strains isolated from blood were retrieved and subjected to core genome-based phylogenomic analysis with Roary. The virulome and resistome were searched with abricate using the VFDB and CARD databases.
Analysis showed that, in addition to V. cholerae, Vibrio paracholerae also causes bacteraemia. The NOVC group was highly diverse, although genomes from different countries were related. Most bacteraemic Vibrios came from countries not affected by epidemic/endemic cholera. The NOVCs virulome presented factors, such as type III and VI secretion systems, HapA, HlyA, RTX, and TLH. Importantly, no resistance to third-generation cephalosporin has been identified in the resistome of NOVCs.
The presence of multiple NOVC lineages that cause bacteraemia in different parts of the world shows that there is no geographic and socioeconomic restriction for these cases. Therefore, healthcare systems need to be aware of this uncommon but deadly Vibrio infection.
引起菌血症的非O1群和非O139群霍乱弧菌（NOVC）已引起全球公共卫生界的关注，主要是由于爆发的可能性以及治疗此类感染的方法。
鉴定与菌血症相关的霍乱弧菌谱系及其抗生素耐药性和毒力因子。
检索与从血液中分离出的菌株相关的霍乱弧菌基因组，并使用Roary进行基于核心基因组的系统发育基因组分析。使用abricate通过VFDB和CARD数据库搜索毒力组和耐药组。
分析表明，除霍乱弧菌外，副霍乱弧菌也可引起菌血症。尽管来自不同国家的基因组相关，但NOVC组具有高度多样性。大多数菌血症性弧菌来自未受流行性/地方性霍乱影响的国家。NOVC的毒力组呈现出III型和VI型分泌系统、HapA、HlyA、RTX和TLH等因子。重要的是，在NOVC的耐药组中未发现对第三代头孢菌素的耐药性。
在世界不同地区存在多种导致菌血症的NOVC谱系，这表明这些病例不存在地理和社会经济限制。因此，医疗保健系统需要意识到这种罕见但致命的弧菌感染。
