Zhang Xiaohui, Lu Yanfei, Qian Huimin, Liu Genyan, Mei Yaning, Jin Fei, Xia Wenying, Ni Fang
Department of Laboratory Medicine, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, People's Republic of China.
National Key Clinical Department of Laboratory Medicine, Nanjing, People's Republic of China.
Infect Drug Resist. 2020 Apr 7;13:1009-1016. doi: 10.2147/IDR.S245806. eCollection 2020.
Non-O1, non-O139 (NOVC) does not agglutinate with O1 and O139 antisera and can cause intestinal and extraintestinal infections in immunocompromised individuals. NOVC bacteremia has the highest mortality among NOVC infections, and the number of reports has increased in recent years. Nevertheless, some clinicians are poorly informed about this disease. Herein, we describe a documented case of NOVC bacteremia in a male patient with impaired liver function. Blood cultures revealed the presence of , but this strain showed self-coagulation on the serum agglutination test. To our knowledge, this phenomenon is unreported among cases of NOVC infections. This pathogen was finally confirmed as NOVC via PCR. Because the patient worked as a garbage transporter, he was likely infected after contact with contaminated water through a foot wound. The patient developed septic shock shortly after admission and ultimately died from the illness. This paper reviews 23 cases of NOVC bacteremia from 2015 to 2019. To improve the accuracy of identifying NOVC and analyze its virulence factors, relevant detection methods were reviewed and analyzed.
非O1、非O139（NOVC）不与O1和O139抗血清发生凝集反应，可在免疫功能低下的个体中引起肠道和肠外感染。NOVC菌血症在NOVC感染中死亡率最高，近年来报告数量有所增加。然而，一些临床医生对这种疾病了解甚少。在此，我们描述了一例有记录的肝功能受损男性患者发生NOVC菌血症的病例。血培养显示有 ，但该菌株在血清凝集试验中表现出自身凝集。据我们所知，这种现象在NOVC感染病例中尚未见报道。该病原体最终通过聚合酶链反应（PCR）确认为NOVC。由于该患者是一名垃圾转运工，他很可能是通过足部伤口接触受污染的水后被感染的。患者入院后不久发生感染性休克，最终因病死亡。本文回顾了2015年至2019年的23例NOVC菌血症病例。为提高识别NOVC的准确性并分析其毒力因子，对相关检测方法进行了回顾和分析。
