Ravindran Sriram, George Anne
Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Adv Exp Med Biol. 2015;881:129-42. doi: 10.1007/978-3-319-22345-2_8.
Dentin and bone are mineralized tissue matrices comprised of collagen fibrils and reinforced with oriented crystalline hydroxyapatite. Although both tissues perform different functionalities, they are assembled and orchestrated by mesenchymal cells that synthesize both collagenous and noncollagenous proteins albeit in different proportions. The dentin matrix proteins (DMPs) have been studied in great detail in recent years due to its inherent calcium binding properties in the extracellular matrix resulting in tissue calcification. Recent studies have shown that these proteins can serve both as intracellular signaling proteins leading to induction of stem cell differentiation and also function as nucleating proteins in the extracellular matrix. These properties make the DMPs attractive candidates for bone and dentin tissue regeneration. This chapter will provide an overview of the DMPs, their functionality and their proven and possible applications with respect to bone tissue engineering.
牙本质和骨是矿化组织基质，由胶原纤维组成，并用定向结晶羟基磷灰石增强。尽管这两种组织执行不同的功能，但它们由间充质细胞组装和协调，这些间充质细胞合成胶原和非胶原蛋白质，尽管比例不同。近年来，牙本质基质蛋白（DMPs）因其在细胞外基质中固有的钙结合特性导致组织钙化而得到了详细研究。最近的研究表明，这些蛋白质既可以作为细胞内信号蛋白导致干细胞分化的诱导，也可以在细胞外基质中作为成核蛋白发挥作用。这些特性使DMPs成为骨和牙本质组织再生的有吸引力的候选者。本章将概述DMPs、它们的功能以及它们在骨组织工程方面已证实的和可能的应用。
