Arabkhazaeli Ali, Vijverberg Susanne J H, van Erp Francine C, Raaijmakers Jan A M, van der Ent Cornelis K, Maitland van der Zee Anke H
Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, P.O. Box 80082, David de Wied Building, Universiteitsweg 99, Utrecht, 3508 TB, The Netherlands.
Department of Pediatric Respiratory Medicine, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands.
BMC Pediatr. 2015 Nov 6;15:172. doi: 10.1186/s12887-015-0481-x.
Childhood allergic diseases have a major impact on a child's quality of life, as well as that of their parents. We studied the coexistence of reported allergies in children who use asthma medication. Additionally, we tested the hypothesis that asthma severity is greater among children with certain combinations of co-morbid allergic conditions.
For this cross-sectional study, 703 children (ages 4 to 12 years) from the PACMAN cohort study were selected. All of the children were regular users of asthma medication. The study population was divided into nine subgroups according to parental-reported allergies of the child (hay fever, eczema, food allergy or combinations of these). In order to assess whether these subgroups differed clinically, the groups were compared for child characteristics (age, gender, family history of asthma), asthma exacerbations in the past year (oral corticosteroids (OCS) use; asthma-related emergency department (ED) visits), asthma control, fractional exhaled nitric oxide level (FeNO), and antihistaminic usage.
In our study, 79.0% of the parents reported that their child suffered from at least one atopic condition (hay fever, food allergy and eczema), and one quarter of the parents (25.6%) reported that their child suffered from all three atopic conditions. Having more than one atopic condition was associated with an increased risk of OCS use (OR = 3.3, 95% CI = 1.6 - 6.6), ED visits (OR = 2.3, 95% CI = 1.2 - 4.6) in the past year and inadequate short term asthma control (OR = 1.9, 95% CI = 1.3 - 2.8).
Children who use asthma medication often also have other allergic conditions. Parental reported allergies were associated with a higher risk of more severe asthma (more asthma complaints and more asthma exacerbations).
儿童过敏性疾病对儿童及其父母的生活质量有重大影响。我们研究了使用哮喘药物的儿童中报告的过敏症共存情况。此外，我们检验了以下假设：患有某些合并症过敏性疾病组合的儿童哮喘严重程度更高。
对于这项横断面研究，从PACMAN队列研究中选取了703名儿童（4至12岁）。所有儿童均为哮喘药物的常规使用者。根据父母报告的儿童过敏情况（花粉症、湿疹、食物过敏或这些情况的组合），将研究人群分为九个亚组。为了评估这些亚组在临床上是否存在差异，比较了各组的儿童特征（年龄、性别、哮喘家族史）、过去一年的哮喘加重情况（口服皮质类固醇（OCS）使用情况；与哮喘相关的急诊科（ED）就诊情况）、哮喘控制情况、呼出一氧化氮分数水平（FeNO）和抗组胺药使用情况。
在我们的研究中，79.0%的父母报告他们的孩子患有至少一种特应性疾病（花粉症、食物过敏和湿疹），四分之一的父母（25.6%）报告他们的孩子患有所有三种特应性疾病。患有不止一种特应性疾病与过去一年中使用OCS的风险增加（OR = 3.3，95%CI = 1.6 - 6.6）、ED就诊风险增加（OR = 2.3，95%CI = 1.2 - 4.6）以及短期哮喘控制不佳风险增加（OR = 1.9，95%CI = 1.3 - 2.8）相关。
使用哮喘药物的儿童通常也患有其他过敏性疾病。父母报告的过敏与更严重哮喘（更多哮喘症状和更多哮喘加重）的较高风险相关。
