Suppr超能文献

成人脊髓髓内畸胎瘤:一例报告并文献复习

Adult Intramedullary Teratoma of the Spinal Cord: A Case Report and Review of Literature.

作者信息

Turan Nefize, Halani Sameer H, Baum Griffin R, Neill Stewart G, Hadjipanayis Constantinos G

机构信息

Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.

出版信息

World Neurosurg. 2016 Mar;87:661.e23-30. doi: 10.1016/j.wneu.2015.10.053. Epub 2015 Nov 4.

Abstract

BACKGROUND

Teratomas of the spinal cord constitute 0.1% of all spinal tumors, and these lesions are extremely rare in adults. The authors describe a rare case of intradural intramedullary teratoma of the conus medullaris and perform review of literature of intramedullary teratomas seen in the thoracolumbar region.

CASE DESCRIPTION

A 48-year-old man presented with fasciculations in the bilateral upper and lower extremities. Radiologic findings revealed an L2-L3 level intradural, nonenhancing, extramedullary cystic mass measuring 15 × 13 mm with a 6-mm enhancing nodule at the level of the conus medullaris. The patient was followed up for 1 year, during which time enlargement of the lesion with new areas of patchy contrast enhancement were observed. L1-L2 decompressive laminectomies were performed, and gross total resection of the lesion was achieved. Histopathologic examination confirmed the diagnosis of benign mature cystic teratoma. A literature review revealed no incidence difference in intramedullary teratomas between males and females (P > 0.05). The mean age at the time of diagnosis was 36.4 ± 12.3 years for men and 41.3 ± 11.6 for women (P < 0.05). The mean symptom duration before treatment was 64.6 ± 79.4 months for females and 20.7 ± 13.8 months for men (P < 0.05). Complete resection was achieved in 48.1% of the cases.

CONCLUSIONS

Teratomas should be taken into consideration in the differential diagnosis of intramedullary lesions when the imaging reveals variable signal intensity because of tissue heterogeneity. A partial resection is a viable treatment option when the lesion is attached to vital structures because of the low recurrence rates reported in the literature.

摘要

背景

脊髓畸胎瘤占所有脊髓肿瘤的0.1%,在成人中极为罕见。作者描述了一例罕见的圆锥髓内硬膜内畸胎瘤病例,并对胸腰段髓内畸胎瘤的文献进行了综述。

病例描述

一名48岁男性出现双侧上下肢肌束震颤。影像学检查发现L2-L3水平硬膜内、无强化的髓外囊性肿块,大小为15×13mm,在圆锥水平有一个6mm的强化结节。对该患者进行了1年的随访,在此期间观察到病变增大并出现新的斑片状强化区域。进行了L1-L2减压椎板切除术,实现了病变的全切除。组织病理学检查确诊为良性成熟囊性畸胎瘤。文献综述显示,男性和女性髓内畸胎瘤的发病率无差异(P>0.05)。男性诊断时的平均年龄为36.4±12.3岁,女性为41.3±11.6岁(P<0.05)。女性治疗前的平均症状持续时间为64.6±79.4个月,男性为20.7±13.8个月(P<0.05)。48.1%的病例实现了完全切除。

结论

当影像学显示由于组织异质性导致信号强度可变时,在髓内病变的鉴别诊断中应考虑畸胎瘤。当病变因与重要结构相连而无法完全切除时,部分切除是一种可行的治疗选择,因为文献报道其复发率较低。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验