Teunis Teun, Janssen Stein, Guitton Thierry G, Ring David, Parisien Robert
General Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Musculoskeletal Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.
Clin Orthop Relat Res. 2016 Jun;474(6):1360-9. doi: 10.1007/s11999-015-4623-0. Epub 2015 Nov 9.
Much of the decision-making in orthopaedics rests on uncertain evidence. Uncertainty is therefore part of our normal daily practice, and yet physician uncertainty regarding treatment could diminish patients' health. It is not known if physician uncertainty is a function of the evidence alone or if other factors are involved. With added experience, uncertainty could be expected to diminish, but perhaps more influential are things like physician confidence, belief in the veracity of what is published, and even one's religious beliefs. In addition, it is plausible that the kind of practice a physician works in can affect the experience of uncertainty. Practicing physicians may not be immediately aware of these effects on how uncertainty is experienced in their clinical decision-making.
QUESTIONS/PURPOSES: We asked: (1) Does uncertainty and overconfidence bias decrease with years of practice? (2) What sociodemographic factors are independently associated with less recognition of uncertainty, in particular belief in God or other deity or deities, and how is atheism associated with recognition of uncertainty? (3) Do confidence bias (confidence that one's skill is greater than it actually is), degree of trust in the orthopaedic evidence, and degree of statistical sophistication correlate independently with recognition of uncertainty?
We created a survey to establish an overall recognition of uncertainty score (four questions), trust in the orthopaedic evidence base (four questions), confidence bias (three questions), and statistical understanding (six questions). Seven hundred six members of the Science of Variation Group, a collaboration that aims to study variation in the definition and treatment of human illness, were approached to complete our survey. This group represents mainly orthopaedic surgeons specializing in trauma or hand and wrist surgery, practicing in Europe and North America, of whom the majority is involved in teaching. Approximately half of the group has more than 10 years of experience. Two hundred forty-two (34%) members completed the survey. We found no differences between responders and nonresponders. Each survey item measured its own trait better than any of the other traits. Recognition of uncertainty (0.70) and confidence bias (0.75) had relatively high Cronbach alpha levels, meaning that the questions making up these traits are closely related and probably measure the same construct. This was lower for statistical understanding (0.48) and trust in the orthopaedic evidence base (0.37). Subsequently, combining each trait's individual questions, we calculated a 0 to 10 score for each trait. The mean recognition of uncertainty score was 3.2 ± 1.4.
Recognition of uncertainty in daily practice did not vary by years in practice (0-5 years, 3.2 ± 1.3; 6-10 years, 2.9 ± 1.3; 11-20 years, 3.2 ± 1.4; 21-30 years, 3.3 ± 1.6 years; p = 0.51), but overconfidence bias did correlate with years in practice (0-5 years, 6.2 ± 1.4; 6-10 years, 7.1 ± 1.3; 11-20 years, 7.4 ± 1.4; 21-30 years, 7.1 ± 1.2 years; p < 0.001). Accounting for a potential interaction of variables using multivariable analysis, less recognition of uncertainty was independently but weakly associated with working in a multispecialty group compared with academic practice (β regression coefficient, -0.53; 95% confidence interval [CI], -1.0 to -0.055; partial R(2), 0.021; p = 0.029), belief in God or any other deity/deities (β, -0.57; 95% CI, -1.0 to -0.11; partial R(2), 0.026; p = 0.015), greater confidence bias (β, -0.26; 95% CI, -0.37 to -0.14; partial R(2), 0.084; p < 0.001), and greater trust in the orthopaedic evidence base (β, -0.16; 95% CI, -0.26 to -0.058; partial R(2), 0.040; p = 0.002). Better statistical understanding was independently, and more strongly, associated with greater recognition of uncertainty (β, 0.25; 95% CI, 0.17-0.34; partial R(2), 0.13; p < 0.001). Our full model accounted for 29% of the variability in recognition of uncertainty (adjusted R(2), 0.29).
The relatively low levels of uncertainty among orthopaedic surgeons and confidence bias seem inconsistent with the paucity of definitive evidence. If patients want to be informed of the areas of uncertainty and surgeon-to-surgeon variation relevant to their care, it seems possible that a low recognition of uncertainty and surgeon confidence bias might hinder adequately informing patients, informed decisions, and consent. Moreover, limited recognition of uncertainty is associated with modifiable factors such as confidence bias, trust in orthopaedic evidence base, and statistical understanding. Perhaps improved statistical teaching in residency, journal clubs to improve the critique of evidence and awareness of bias, and acknowledgment of knowledge gaps at courses and conferences might create awareness about existing uncertainties.
Level 1, prognostic study.
骨科的许多决策都基于不确定的证据。因此,不确定性是我们日常工作的一部分,然而医生对治疗的不确定性可能会损害患者的健康。目前尚不清楚医生的不确定性仅仅是证据本身的作用,还是涉及其他因素。随着经验的增加,不确定性有望减少,但或许更具影响力的是医生的信心、对已发表内容真实性的信念,甚至是个人的宗教信仰。此外,医生的执业类型可能会影响其对不确定性的体验,这似乎是合理的。执业医生可能不会立即意识到这些因素对他们临床决策中不确定性体验的影响。
问题/目的:我们提出了以下问题:(1)不确定性和过度自信偏差是否会随着执业年限的增加而降低?(2)哪些社会人口统计学因素与对不确定性的认识较低独立相关,特别是对上帝或其他神灵的信仰,以及无神论与对不确定性的认识有何关联?(3)信心偏差(认为自己的技能高于实际水平的信心)、对骨科证据的信任程度以及统计专业程度是否与对不确定性的认识独立相关?
我们设计了一项调查问卷,以确定对不确定性的总体认识得分(四个问题)、对骨科证据基础的信任度(四个问题)、信心偏差(三个问题)以及统计理解能力(六个问题)。我们邀请了706名变异科学小组的成员参与完成我们的调查,该小组旨在研究人类疾病定义和治疗中的变异情况。这个小组主要由专注于创伤或手与腕部手术的骨科医生组成,他们在欧洲和北美执业,其中大多数人参与教学工作。该小组中约一半的成员拥有超过10年的经验。242名(34%)成员完成了调查。我们发现回答者和未回答者之间没有差异。每个调查项目对其自身特质的测量效果优于其他任何特质。对不确定性的认识(0.70)和信心偏差(0.75)具有相对较高的克朗巴哈系数水平,这意味着构成这些特质的问题紧密相关,可能测量的是同一结构。统计理解能力(0.48)和对骨科证据基础的信任度(0.37)的克朗巴哈系数则较低。随后,我们将每个特质的各个问题进行综合,为每个特质计算了一个0至10分的得分。对不确定性的认识得分平均值为3.2±1.4。
日常实践中对不确定性的认识不会因执业年限而有所不同(0至5年,3.2±1.3;6至10年,2.9±1.3;11至20年,3.2±1.4;21至30年,3.3±1.6年;p = 0.51),但过度自信偏差确实与执业年限相关(0至5年,6.2±1.4;6至10年,7.1±1.3;11至20年,7.4±1.4;21至30年,7.1±1.2年;p < 0.001)。使用多变量分析考虑变量之间的潜在相互作用后,与学术实践相比,在多专科团队中工作与对不确定性的认识较低独立但微弱相关(β回归系数,-0.53;95%置信区间[CI],-1.0至-0.055;偏R(2),0.021;p = 0.029),对上帝或任何其他神灵的信仰(β,-0.57;95%CI,-1.0至-0.11;偏R(2),0.026;p = 0.015),更大的信心偏差(β,-0.26;95%CI,-0.37至-0.14;偏R(2),0.084;p < 0.001),以及对骨科证据基础的更高信任度(β,-0.16;95%CI,-0.26至-0.058;偏R(2),0.040;p = 0.002)。更好的统计理解能力与对不确定性的更高认识独立且更强烈相关(β,0.25;95%CI,0.17 - 0.34;偏R(2),0.13;p < 0.001)。我们的完整模型解释了对不确定性认识中29%的变异性(调整后R(2),0.29)。
骨科医生中相对较低的不确定性水平和信心偏差似乎与确凿证据的匮乏不一致。如果患者希望了解与其治疗相关的不确定性领域以及医生之间的差异,那么对不确定性的低认识和医生的信心偏差可能会阻碍充分告知患者、帮助其做出明智决策以及获得知情同意。此外,对不确定性的有限认识与一些可改变的因素相关,如信心偏差、对骨科证据基础的信任度以及统计理解能力。或许在住院医师培训中加强统计教学、通过期刊俱乐部提高对证据的批判性分析和对偏差的认识,以及在课程和会议中承认知识差距,可能会提高对现有不确定性的认识。
1级,预后研究。