Fassoulaki A, Eforakopoulou M
Department of Intensive Care, St Savas Hospital, Athens, Greece.
Crit Care Med. 1989 Jun;17(6):527-9. doi: 10.1097/00003246-198906000-00008.
The cardiovascular, respiratory and metabolic effects of pressure-supported ventilation with 7, 14 and 21 cm H2O were studied in 16 spontaneously breathing patients convalescing from severe illness. No statistically significant changes occurred in the hemodynamic variables, although CVP and urine output were increased at the higher levels of pressure support. Minute volume and blood gases did not change. Pressure-supported ventilation was associated with a statistically significant decrease in respiratory rate (p less than .002), a significant increase in tidal volume (p less than .01) and in mean airway pressure (p less than .001). Oxygen consumption, CO2 production, and resting energy expenditure were reduced by 14% to 20%, 17% to 25% and 10% to 18%, respectively, the decrease being proportional to the level of pressure support. These changes of the metabolic variables were not found to be statistically significant.
对16例从重症中康复的自主呼吸患者，研究了7厘米水柱、14厘米水柱和21厘米水柱压力支持通气对心血管、呼吸和代谢的影响。血流动力学变量未发生统计学显著变化，尽管在较高压力支持水平时中心静脉压和尿量增加。每分通气量和血气未改变。压力支持通气与呼吸频率统计学显著降低（p<0.002）、潮气量显著增加（p<0.01）以及平均气道压显著增加（p<0.001）相关。氧耗量、二氧化碳产生量和静息能量消耗分别降低了14%至20%、17%至25%和10%至18%，降低程度与压力支持水平成正比。这些代谢变量的变化未发现具有统计学显著性。
