Hasan Khader M, Mwangi Benson, Cao Bo, Keser Zafer, Tustison Nicholas J, Kochunov Peter, Frye Richard E, Savatic Mirjana, Soares Jair
Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center, Houston, TX.
Department of Diagnostic and Psychiatry, University of Texas Health Science Center, Houston, TX.
J Neuroimaging. 2016 May;26(3):278-82. doi: 10.1111/jon.12297. Epub 2015 Oct 8.
Human entorhinal cortex (ERC) connects the temporal neocortex with hippocampus and is essential for memory retrieval and navigation. Markedly, there have been only few quantitative MRI works on the ERC geometric measurements in pediatric and adult healthy subjects across the lifespan. Here, we sought to fill this gap in knowledge by quantifying the ERC thickness in a very large cohort of subjects spanning 9 decades of life.
Using magnetic resonance imaging data from multiple centers (IXI, MMRR, NKI, OASIS combined with the NIH-Child Dev database and locally recruited healthy subjects), we analyzed the lifespan trajectory of ERC thickness in 1,660 healthy controls ranging from 2 to 94 years of age.
The ERC thickness increased with age, reached a peak at about 44 years, and then decreased with age. ERC thickness is hemispherically rightward-asymmetric with no gender differences. Mean ERC thickness was found to vary between 2.943 ± .438 mm and 3.525 ± .355 mm across different age populations. Also, more pronounced loss of the ERC thickness in healthy aging men was noticeable.
Our report with high spatial resolution brain MRI data from 1,660 healthy controls provided important clues about ERC thickness across lifespan. We believe that our report will pave the way for the future studies investigating distinct neural pathologies related with cognitive dysfunctions.
人类内嗅皮质（ERC）连接颞叶新皮质和海马体，对记忆提取和导航至关重要。值得注意的是，在整个生命周期中，针对儿科和成人健康受试者的ERC几何测量的定量MRI研究很少。在此，我们试图通过对跨越9个年龄段的大量受试者队列的ERC厚度进行量化，来填补这一知识空白。
利用来自多个中心（IXI、MMRR、NKI、OASIS，结合美国国立卫生研究院儿童发育数据库和本地招募的健康受试者）的磁共振成像数据，我们分析了1660名年龄在2至94岁之间的健康对照者的ERC厚度的生命周期轨迹。
ERC厚度随年龄增长而增加，在约44岁时达到峰值，然后随年龄下降。ERC厚度在半球上向右不对称，无性别差异。发现在不同年龄人群中，平均ERC厚度在2.943±0.438毫米至3.525±0.355毫米之间变化。此外，健康老年男性的ERC厚度损失更为明显。
我们对1660名健康对照者的具有高空间分辨率的脑MRI数据的报告，提供了有关整个生命周期中ERC厚度的重要线索。我们相信，我们的报告将为未来研究与认知功能障碍相关的不同神经病理学铺平道路。
