Department of Anaesthesia and Peri-operative Medicine, Alfred Hospital, Melbourne, Victoria, Australia.
Department of Anaesthesia, Austin Hospital, Melbourne, Victoria, Australia.
Anaesthesia. 2016 Feb;71(2):192-7. doi: 10.1111/anae.13292. Epub 2015 Nov 14.
We allocated 52 participants to oral pregabalin 300 mg and 48 participants to placebo tablets before thoracoscopic surgery and for five postoperative days. The median (IQR [range]) cumulative pain scores at rest for nine postoperative months were 184 (94-274 [51-1454]) after pregabalin and 166 (66-266 [48-1628]) after placebo, p = 0.39. The corresponding scores on deep breathing were 468 (281-655 [87-2870]) and 347 (133-561 [52-3666]), respectively, p = 0.16. After three postoperative months, 29/100 participants had persistent surgical site pain, 19/52 after pregabalin and 10/48 after placebo, p = 0.12, of whom four and five, respectively, attended a pain management clinic, p = 0.24. The median (IQR [range]) morphine equivalent consumption six days after surgery was 273 (128-619 [39-2243]) mg after pregabalin and 319 (190-663 [47-2258]) mg after placebo, p = 0.35.
我们将 52 名参与者分配到口服普瑞巴林 300mg 组，48 名参与者分配到安慰剂组，在胸腔镜手术前和术后 5 天使用。术后 9 个月静息时累积疼痛评分的中位数（IQR [范围]），普瑞巴林组为 184（94-274 [51-1454]），安慰剂组为 166（66-266 [48-1628]），p=0.39。相应的深呼吸评分分别为 468（281-655 [87-2870]）和 347（133-561 [52-3666]），p=0.16。术后 3 个月时，100 名参与者中有 29 名（29%）持续存在手术部位疼痛，普瑞巴林组为 19 名（37%），安慰剂组为 10 名（21%），p=0.12，其中分别有 4 名和 5 名参加了疼痛管理诊所，p=0.24。术后 6 天吗啡等效消耗量的中位数（IQR [范围]），普瑞巴林组为 273（128-619 [39-2243]）mg，安慰剂组为 319（190-663 [47-2258]）mg，p=0.35。
