光、褪黑素及其他褪黑素受体激动剂对人体昼夜生理的影响。
Effect of Light and Melatonin and Other Melatonin Receptor Agonists on Human Circadian Physiology.
作者信息
Emens Jonathan S, Burgess Helen J
机构信息
Department of Hospital and Specialty Medicine, Portland VA Medical Center, 3710 SW US Veterans Hospital Road, P3-PULM, Portland, OR 97239, USA; Departments of Psychiatry and Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Biological Rhythms Research Laboratory, Department of Behavioral Sciences, Rush University Medical Center, 1645 West Jackson Boulevard, Suite 425, Chicago, IL 60612, USA.
出版信息
Sleep Med Clin. 2015 Dec;10(4):435-53. doi: 10.1016/j.jsmc.2015.08.001. Epub 2015 Sep 7.
Abstract
Circadian (body clock) timing has a profound influence on mental health, physical health, and health behaviors. This review focuses on how light, melatonin, and other melatonin receptor agonist drugs can be used to shift circadian timing in patients with misaligned circadian rhythms. A brief overview of the human circadian system is provided, followed by a discussion of patient characteristics and safety considerations that can influence the treatment of choice. The important features of light treatment, light avoidance, exogenous melatonin, and other melatonin receptor agonists are reviewed, along with some of the practical aspects of light and melatonin treatment.
摘要
昼夜节律（生物钟）对心理健康、身体健康和健康行为有着深远影响。本综述聚焦于如何利用光线、褪黑素及其他褪黑素受体激动剂药物来调整昼夜节律失调患者的昼夜节律。文中首先简要概述了人体昼夜节律系统，接着讨论了可能影响治疗选择的患者特征和安全考量。随后回顾了光照治疗、避光、外源性褪黑素及其他褪黑素受体激动剂的重要特点，以及光照和褪黑素治疗的一些实际情况。
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