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日本西部学龄儿童中颗粒物对肺功能影响的差异及其与白细胞介素-8的关系

Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8.

作者信息

Watanabe Masanari, Noma Hisashi, Kurai Jun, Sano Hiroyuki, Kitano Hiroya, Saito Rumiko, Kimura Yutaka, Aiba Setsuya, Oshimura Mitsuo, Shimizu Eiji

机构信息

Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan.

Department of Data Science, Institute of Statistical Mathematics, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, Japan.

出版信息

Int J Environ Res Public Health. 2015 Nov 9;12(11):14229-43. doi: 10.3390/ijerph121114229.

DOI:10.3390/ijerph121114229
PMID:26569272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4661643/
Abstract

This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April-May 2012, and in 384 of these children during March-May 2013. PEF's association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 mm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 mg/m³ in SPM led to PEF changes of -2.16 L/min in 2012 and -0.81 L/min in 2013, respectively. An increment of 10.7 mg/m³ in PM2.5 was associated with PEF changes of -2.58 L/min in 2012 and -0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM2.5, but this association may differ depending on the PM's ability to elicit interleukin-8 production.

摘要

本研究旨在调查颗粒物（PM）对学童肺功能的影响，以及这些影响与白细胞介素-8的关系。2012年4月至5月期间，对399名儿童每日测量晨峰呼气流量（PEF），2013年3月至5月期间，对其中384名儿童进行测量。使用线性混合模型估计PEF与每日悬浮颗粒物（SPM）和直径小于2.5毫米的颗粒物（PM2.5）水平之间的关联。在鸟取大学医院四个时间段（2012年两个时间段和2013年两个时间段）收集的沉降PM刺激的THP-G8细胞中评估白细胞介素-8启动子活性。SPM每增加14.0毫克/立方米，导致2012年和2013年的PEF变化分别为-2.16升/分钟和-0.81升/分钟。PM2.5每增加10.7毫克/立方米，分别与2012年和2013年的PEF变化-2.58升/分钟和-0.55升/分钟相关。这些关联仅在2012年具有显著性。2012年的两个时间段白细胞介素-8启动子活性均显著高于2013年。学童肺功能与SPM和PM2.5的每日水平之间存在显著关联，但这种关联可能因PM引发白细胞介素-8产生的能力不同而有所差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/839d9b20ebb1/ijerph-12-14229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/1fad6664a1f0/ijerph-12-14229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/1964e0008b10/ijerph-12-14229-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/839d9b20ebb1/ijerph-12-14229-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/1fad6664a1f0/ijerph-12-14229-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/1964e0008b10/ijerph-12-14229-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec46/4661643/839d9b20ebb1/ijerph-12-14229-g003.jpg

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