Department of Biomedical Engineering, Duke University, Room 1427, Fitzpatrick CIEMAS, 101 Science Drive, Campus Box 90281, Durham, NC 27708, USA.
Adv Drug Deliv Rev. 2016 Feb 1;97:250-9. doi: 10.1016/j.addr.2015.11.004. Epub 2015 Nov 10.
Tumor angiogenesis is a hallmark of cancer that has been identified as a critical component of cancer progression, facilitating rapid tumor growth and metastasis. Anti-angiogenic therapies have exhibited only modest clinical success, highlighting a need for better models that can be used to gain a more thorough understanding of tumor angiogenesis and screen potential therapeutics more accurately. This review explores how recent progress in in vitro cancer and vascular models individually can be applied to the development of in vitro tumor angiogenesis models. Current in vitro tumor angiogenesis models are also discussed, with a focus on aspects of the process that have been successfully recapitulated and opportunities for applying new technologies to expand model complexity to better represent the tumor microenvironment. Continued advances in vascularized tumor models will provide tools to identify novel therapeutic targets and validate their therapeutic benefit.
肿瘤血管生成是癌症的一个标志，已被确定为癌症进展的关键组成部分，促进了肿瘤的快速生长和转移。抗血管生成疗法仅取得了适度的临床成功，这凸显了需要更好的模型，以便更深入地了解肿瘤血管生成，并更准确地筛选潜在的治疗方法。这篇综述探讨了最近在体外癌症和血管模型方面的进展如何分别应用于体外肿瘤血管生成模型的开发。还讨论了当前的体外肿瘤血管生成模型，重点介绍了已成功再现的过程方面以及应用新技术扩展模型复杂性以更好地代表肿瘤微环境的机会。血管化肿瘤模型的持续进展将为识别新的治疗靶点并验证其治疗益处提供工具。
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