新型聚酮合酶底物生物合成的最新进展。
Recent advances in the biosynthesis of unusual polyketide synthase substrates.
作者信息
Ray Lauren, Moore Bradley S
机构信息
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.
出版信息
Nat Prod Rep. 2016 Feb;33(2):150-61. doi: 10.1039/c5np00112a.
Abstract
This highlight provides an overview of recent advances in understanding the diversity of polyketide synthase (PKS) substrate building blocks. Substrates functioning as starter units and extender units contribute significantly to the chemical complexity and structural diversity exhibited by this class of natural products. This article complements and extends upon the current comprehensive reviews that have been published on these two topics (Moore and Hertweck, Nat. Prod. Rep., 2002, 19, 70; Chan et al., Nat. Prod. Rep., 2009, 1, 90; Wilson and Moore, Nat. Prod. Rep., 2012, 29, 72).
摘要
本综述重点介绍了在理解聚酮合酶（PKS）底物结构单元多样性方面的最新进展。作为起始单元和延伸单元发挥作用的底物，对这类天然产物所展现出的化学复杂性和结构多样性有显著贡献。本文对已发表的关于这两个主题的当前全面综述进行了补充和扩展（Moore和Hertweck，《天然产物报告》，2002年，第19卷，第70页；Chan等人，《天然产物报告》，2009年，第1卷，第90页；Wilson和Moore，《天然产物报告》，2012年，第29卷，第72页）。
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Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13462-5. doi: 10.1002/anie.201506899. Epub 2015 Sep 10.
2
Reinvigorating natural product combinatorial biosynthesis with synthetic biology.
Nat Chem Biol. 2015 Sep;11(9):649-59. doi: 10.1038/nchembio.1893.
3
Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds.
J Am Chem Soc. 2015 Apr 1;137(12):4183-90. doi: 10.1021/jacs.5b00728. Epub 2015 Mar 19.
4
Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology.
Trends Biochem Sci. 2015 Apr;40(4):189-99. doi: 10.1016/j.tibs.2015.02.001. Epub 2015 Mar 7.
5
Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides.
Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2370-3. doi: 10.1002/anie.201410124. Epub 2015 Jan 7.
6
Insights into the pamamycin biosynthesis.
Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2280-4. doi: 10.1002/anie.201408901. Epub 2014 Dec 23.
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De novo biosynthesis of terminal alkyne-labeled natural products.
Nat Chem Biol. 2015 Feb;11(2):115-20. doi: 10.1038/nchembio.1718. Epub 2014 Dec 22.
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