Ghenghesh Khalifa Sifaw, Rahouma Amal, Zorgani Abdulaziz, Tawil Khaled, Al Tomi Abdurazzaq, Franka Ezzadin
El-Nakheel Compound, El-Sherouk City, Cairo, Egypt.
Faculty of Medicine, University of Tripoli, Tripoli, Libya.
Comp Immunol Microbiol Infect Dis. 2015 Oct;42:8-14. doi: 10.1016/j.cimid.2015.07.002. Epub 2015 Aug 1.
The aim of this review is to provide information on the prevalence, clinical syndromes, and antimicrobial resistance and therapy of Aeromonas spp. infections in Arab countries. The data were obtained by an English language literature search from 1995 to 2014 of Medline and PubMed for papers using the search terms "Aeromonas+name of Arab country (i.e. Algeria, Egypt, etc.)". Additional data were obtained from a Google search using the aforementioned terms. The organisms have been reported from diarrheal children, patients with cholera-like diarrhea, an outbreak of acute gastroenteritis and from different types of animals, foods and water source in several Arab countries in the Middle East and North Africa with predominance of A. hydrophila, A. caviae and A. sobria. Using molecular techniques few studies reported genes encoding several toxins from aeromonads isolated from different sources. Among the antimicrobials examined in the present review third generation cephalosporins, fluoroquinolones and aminoglycosides showed excellent activity and can be employed in the treatment of Aeromonas-associated human infections in Arabic countries. Whenever possible, treatment should be guided by the susceptibility testing results of the isolated organism. In the future, studies employing molecular testing methods are required to provide data on circulating genospecies and their modes of transmission in the community, and on their mechanisms of resistance to antimicrobials. Microbiology laboratories and research centers are encouraged to look for these organisms in clinical, food and water sources to attain a better understanding of the public health risks from these organisms in Arab countries.
本综述的目的是提供关于阿拉伯国家气单胞菌属感染的患病率、临床综合征、抗菌药物耐药性及治疗方面的信息。数据通过对1995年至2014年的Medline和PubMed进行英文文献检索获得，检索词为“气单胞菌属 + 阿拉伯国家名称（如阿尔及利亚、埃及等）”。另外的数据通过使用上述检索词在谷歌搜索中获得。在中东和北非的几个阿拉伯国家，腹泻儿童、霍乱样腹泻患者、急性肠胃炎暴发以及不同类型的动物、食物和水源中均报告有该菌，其中嗜水气单胞菌、豚鼠气单胞菌和温和气单胞菌占主导。使用分子技术的少数研究报告了从不同来源分离的气单胞菌中编码几种毒素的基因。在本综述中所检测的抗菌药物中，第三代头孢菌素、氟喹诺酮类和氨基糖苷类显示出优异的活性，可用于治疗阿拉伯国家与气单胞菌相关的人类感染。只要有可能，治疗应根据分离菌株的药敏试验结果来指导。未来，需要采用分子检测方法的研究来提供关于社区中流行的基因种及其传播方式以及它们对抗菌药物耐药机制的数据。鼓励微生物学实验室和研究中心在临床、食物和水源中寻找这些细菌，以便更好地了解阿拉伯国家这些细菌所带来的公共卫生风险。
