Gaascht François, Dicato Mario, Diederich Marc
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC), Hôpital Kirchberg, 9 Rue Edward Steichen, 2540, Luxembourg, Luxembourg.
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, 18016, Armilla, Granada, Spain.
Genes Nutr. 2015 Nov;10(6):51. doi: 10.1007/s12263-015-0501-3. Epub 2015 Nov 17.
Coffee is the second most popular beverage in the world after water with a consumption of approximately two billion cups per day. Due to its low cost and ease of preparation, it is consumed in almost all countries and by all social classes of the population through different modes of preparation. Despites its simple appearance, a cup of coffee is in fact a complex mixture that contains hundreds of molecules, the composition and concentration of which vary widely and depend on factors including the origin of the coffee tree or its metabolism. Although an excessive consumption of coffee can be harmful, many molecules that are present in this black decoction exert anticancer properties. This review aims to describe the different primary coffee-containing substances that exert chemopreventive and bioactive activities against the different hallmarks and enabling characteristics of cancer, thus explaining the anticancer health benefit of black coffee.
咖啡是世界上仅次于水的第二大受欢迎饮品，每天的消费量约为20亿杯。由于其成本低且易于制备，几乎所有国家的各社会阶层人群都通过不同的制备方式饮用咖啡。尽管一杯咖啡外观简单，但实际上是一种复杂的混合物，含有数百种分子，其成分和浓度差异很大，取决于咖啡豆的产地或其新陈代谢等因素。虽然过量饮用咖啡可能有害，但这种黑色煎剂中存在的许多分子具有抗癌特性。本综述旨在描述不同的主要含咖啡物质，这些物质对癌症的不同特征和促成特性具有化学预防和生物活性作用，从而解释黑咖啡对健康的抗癌益处。
