Uchida Ryuji, Ishikawa Seiko, Tomoda Hiroshi
Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan ; School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.
Acta Pharm Sin B. 2014 Apr;4(2):141-5. doi: 10.1016/j.apsb.2013.12.008. Epub 2014 Mar 21.
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
2-羟基酪醇（2-HT）最初被报道为一种合成化合物，后来首次作为真菌代谢产物被分离出来。研究发现，2-HT对蘑菇酪氨酸酶具有抑制作用，其半数抑制浓度（IC50）为13.0微摩尔/升。此外，2-HT对B16黑色素瘤细胞无细胞提取物中的酪氨酸酶活性呈剂量依赖性抑制（IC50为32.5微摩尔/升），并能抑制完整B16黑色素瘤细胞中α-黑素细胞刺激素（α-MSH）刺激的黑色素生成。
Zotero 插件
