一项为期两年的监督锻炼计划对HIV感染患者身体成分和肌肉表现的影响。
Effects of a 2-Year Supervised Exercise Program Upon the Body Composition and Muscular Performance of HIV-Infected Patients.
作者信息
Paes Lorena da Silva, Borges Juliana Pereira, Dos Santos Fernanda Monteiro, de Oliveira Taciana Pinto, Dupin Jaciara Gomes, Harris Elizabeth Assumpção, Farinatti Paulo
机构信息
Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil.
Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil ; Graduate Program in Physical Activity Sciences, Salgado de Oliveira University, Niteroi, RJ, Brazil.
出版信息
Open AIDS J. 2015 Oct 20;9:80-8. doi: 10.2174/1874613601509010080. eCollection 2015.
BACKGROUND
There is a lack of research investigating long-term effects of exercise training upon the body composition and muscle function in HIV-infected patients (PHIV). The study investigated the influence of a 2-year supervised exercise program on body composition and strength of PHIV under highly active antiretroviral therapy (HAART).
METHODS
A training program including aerobic, strength and flexibility exercises was performed by 27 PHIV (17 men/ 10 women; age: 48.7±7.0 years; HAART: 150.7±65.3 months) during 1 year and 18 PHIV (10 men/ 8 women; age: 50.6±5.2 years; HAART: 176.6±53.1 months) during 2 years. Body composition and knee isokinetic strength were assessed at baseline and at the end of each year of intervention.
RESULTS
Body composition remained stable along the whole experiment vs baseline (1-year - total muscle mass: Δ men=1.1%, P=0.21; Δ women=1.4%, P=0.06; trunk fat: Δ men=-0.1%, P=0.65; Δ women=-1.5%, P=0.45; 2 years - total muscle mass: Δ men=2.7%, P=0.54; Δ women=-1.9%, P=0.71; trunk fat: Δ men=4.4%, P=0.96; Δ women=10.0%, P=0.30). After 1-year, peak torque increased in men (Δ extension=4.2%, P=0.01; Δ flexion=12.2%, P=0.04) and total work reduced in women (Δ extension=-15.4%, P=0.01, Δ flexion=-17.5%, P=0.05). All strength markers remained stable vs baseline after 2 years of intervention (P>0.05). Only men showed significant reduction in the risk of disability due to sarcopenia (P=0.05) after 1 year of intervention, which remained stable after 2 years.
CONCLUSION
Long-term exercise training preserved strength and muscle mass in PHIV under HAART. Exercise programs should be part of HIV therapy to prevent sarcopenia of this population along the years.
TRIAL REGISTRATION
ACTRN12610000683033; UTN U1111-1116-4416.
背景
缺乏关于运动训练对HIV感染患者（PHIV）身体成分和肌肉功能长期影响的研究。本研究调查了在高效抗逆转录病毒治疗（HAART）下，一项为期2年的有监督运动计划对PHIV身体成分和力量的影响。
方法
27名PHIV患者（17名男性/10名女性；年龄：48.7±7.0岁；HAART治疗时间：150.7±65.3个月）进行了为期1年的包括有氧运动、力量训练和柔韧性训练的计划，18名PHIV患者（10名男性/8名女性；年龄：50.6±5.2岁；HAART治疗时间：176.6±53.1个月）进行了为期2年的该计划。在基线时以及干预每年结束时评估身体成分和膝关节等速力量。
结果
与基线相比，整个实验过程中身体成分保持稳定（1年 - 总肌肉量：男性增加1.1%，P = 0.21；女性增加1.4%，P = 0.06；躯干脂肪：男性减少0.1%，P = 0.65；女性减少1.5%，P = 0.45；2年 - 总肌肉量：男性增加2.7%，P = 0.54；女性减少1.9%，P = 0.71；躯干脂肪：男性增加4.4%，P = 0.9;女性增加10.0%，P = 0.30）。干预1年后，男性的峰值扭矩增加（伸展增加4.2%，P = 0.01；屈曲增加12.2%，P = 0.04），女性的总功减少（伸展减少15.4%，P = 0.01，屈曲减少17.5%，P = 0.05）。干预2年后，所有力量指标与基线相比保持稳定（P>0.05）。仅男性在干预1年后因肌肉减少症导致残疾的风险显著降低（P = 0.05），2年后保持稳定。
结论
在HAART治疗下，长期运动训练可维持PHIV患者的力量和肌肉量。运动计划应成为HIV治疗的一部分，以预防该人群多年来的肌肉减少症。
试验注册
ACTRN12；UTN U1111-1116-4416。
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