机械通气与支气管肺发育不良

Mechanical Ventilation and Bronchopulmonary Dysplasia.

作者信息

Keszler Martin, Sant'Anna Guilherme

机构信息

Department of Pediatrics, Women and Infants Hospital of Rhode Island, Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA.

Department of Pediatrics, Neonatal Division, Montreal Children's Hospital, McGill University, 1001 Decarie Boulevard, Room B05.2711, Montreal, Quebec H4A 3J1, Canada.

出版信息

Clin Perinatol. 2015 Dec;42(4):781-96. doi: 10.1016/j.clp.2015.08.006. Epub 2015 Oct 1.

DOI:10.1016/j.clp.2015.08.006

PMID:26593078

Abstract

Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-protective ventilation strategies. Avoidance of oxidative stress, less invasive methods of surfactant administration, and high-frequency ventilation are also important factors in lung injury prevention.

摘要

机械通气是支气管肺发育不良发生的一个重要的潜在可改变风险因素。有效使用无创呼吸支持可降低肺损伤风险。肺容积复张和避免大潮气量是肺保护性通气策略的关键要素。避免氧化应激、采用侵入性较小的表面活性剂给药方法以及高频通气也是预防肺损伤的重要因素。