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对患有呼吸窘迫综合征的早产儿实施微创表面活性剂给药(LISA):一项质量改进计划。

Implementation of Less Invasive Surfactant Administration (LISA) for Preterm Neonates with Respiratory Distress Syndrome: A Quality Improvement Initiative.

作者信息

Agrawal Triptee, Phani Priya Mandula, Sundaram Venkataseshan, Kumar Praveen

机构信息

Division of Neonatology, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

出版信息

Indian J Pediatr. 2025 Jul 15. doi: 10.1007/s12098-025-05661-0.

DOI:10.1007/s12098-025-05661-0
PMID:40663233
Abstract

OBJECTIVES

To initiate less invasive surfactant administration (LISA) in authors' unit using a quality improvement (QI) approach and increase LISA rates by 50% over 10 mo period.

METHODS

The authors adopted a QI methodology to address this issue. The proportion of surfactant administration done by the LISA method was the primary outcome indicator. Focused group discussions were conducted with doctors and nurses during the initial phase to identify the root causes. Meetings were conducted where team members were given descriptions of the insertion method, complications and precautions to be taken. All the members were trained to use LISA on mannequins in a simulation lab. They were also trained regarding the fixation of continuous positive airway pressure (CPAP), monitoring of complications and correction steps. Multiple Plan-Do-Study-Act (PDSA) cycles were implemented. A standard operating policy was developed, and all babies requiring surfactant were administered surfactant with the LISA technique.

RESULTS

Over the 10 mo, the proportion of neonates who received surfactant via the LISA method increased from 0 to 90%. Complications such as desaturation (74%), surfactant reflux (32.1%), bradycardia (25%), and unilateral administration of surfactant (26.7%), which were initially observed, gradually decreased to 7.4%, 3.7%, 7.4%, and 7.4%, respectively.

CONCLUSIONS

Utilising QI tools, the authors achieved an increase in the rate of surfactant administration by the LISA method by more than 50%.

摘要

目的

在作者所在科室采用质量改进(QI)方法启动微创表面活性剂给药(LISA),并在10个月内将LISA使用率提高50%。

方法

作者采用QI方法来解决这个问题。LISA方法进行表面活性剂给药的比例是主要结果指标。在初始阶段与医生和护士进行了焦点小组讨论,以确定根本原因。召开了会议,向团队成员介绍了插入方法、并发症及需采取的预防措施。所有成员都在模拟实验室接受了在人体模型上使用LISA的培训。他们还接受了持续气道正压通气(CPAP)固定、并发症监测及纠正步骤方面的培训。实施了多个计划-执行-研究-改进(PDSA)循环。制定了标准操作政策,所有需要表面活性剂的婴儿均采用LISA技术给予表面活性剂。

结果

在这10个月期间,通过LISA方法接受表面活性剂治疗的新生儿比例从0增加到90%。最初观察到的并发症,如血氧饱和度下降(74%)、表面活性剂反流(32.1%)、心动过缓(25%)和表面活性剂单侧给药(26.7%),分别逐渐降至7.4%、3.7%、7.4%和7.4%。

结论

通过使用QI工具,作者使LISA方法的表面活性剂给药率提高了50%以上。

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Guidelines for surfactant replacement therapy in neonates.新生儿表面活性剂替代疗法指南
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Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA.极早产儿应用较少有创性肺表面活性剂后其发育结局改善:LISA 后的发育结局。
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