体外培养的孕早期胎盘中人绒毛膜促性腺激素的自发性、促性腺激素释放激素诱导性及孕酮抑制性脉冲分泌
Spontaneous, gonadotropin-releasing hormone-induced, and progesterone-inhibited pulsatile secretion of human chorionic gonadotropin in the first trimester placenta in vitro.
作者信息
Barnea E R, Kaplan M
机构信息
Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa.
出版信息
J Clin Endocrinol Metab. 1989 Jul;69(1):215-7. doi: 10.1210/jcem-69-1-215.
Using a multichannel superfusion apparatus, the secretion of human chorionic gonadotropin (hCG) was measured at 1-6 minute intervals in placental explants at 7-9 weeks of gestation. hCG was found to be secreted in distinct pulses (4-5 fold above baseline) every 11-23 minutes peak to peak. Addition of one minute pulses of GnRH analog significantly increased, whereas pulses of progesterone decreased, pulsatile hCG secretion.
使用多通道灌注装置，每隔1 - 6分钟测量一次妊娠7 - 9周胎盘外植体中人类绒毛膜促性腺激素（hCG）的分泌量。发现hCG以明显的脉冲形式分泌（比基线高4 - 5倍），峰峰值间隔为每11 - 23分钟一次。添加1分钟脉冲的促性腺激素释放激素（GnRH）类似物可显著增加脉冲式hCG分泌，而孕酮脉冲则会降低其分泌。
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