Department of Biomedical Informatics, Columbia University Medical Center, New York, New York 10032, USA.
Department of Systems Biology, Columbia University Medical Center, New York, New York 10032, USA.
Sci Data. 2015 Nov 24;2:150065. doi: 10.1038/sdata.2015.65.
Animal venoms have been used for therapeutic purposes since the dawn of recorded history. Only a small fraction, however, have been tested for pharmaceutical utility. Modern computational methods enable the systematic exploration of novel therapeutic uses for venom compounds. Unfortunately, there is currently no comprehensive resource describing the clinical effects of venoms to support this computational analysis. We present VenomKB, a new publicly accessible knowledge base and website that aims to act as a repository for emerging and putative venom therapies. Presently, it consists of three database tables: (1) Manually curated records of putative venom therapies supported by scientific literature, (2) automatically parsed MEDLINE articles describing compounds that may be venom derived, and their effects on the human body, and (3) automatically retrieved records from the new Semantic Medline resource that describe the effects of venom compounds on mammalian anatomy. Data from VenomKB may be selectively retrieved in a variety of popular data formats, are open-source, and will be continually updated as venom therapies become better understood.
动物毒液自古以来就被用于治疗目的。然而，只有一小部分毒液经过了药物效用的测试。现代计算方法使人们能够系统地探索毒液化合物的新治疗用途。不幸的是，目前没有全面描述毒液临床作用的资源来支持这种计算分析。我们提出了 VenomKB，这是一个新的公开可访问的知识库和网站，旨在成为新兴和假定的毒液疗法的存储库。目前，它由三个数据库表组成：(1) 有科学文献支持的假定毒液疗法的手动编目记录，(2) 自动解析的描述可能源自毒液的化合物及其对人体影响的 MEDLINE 文章，以及 (3) 自动从新的语义 MEDLINE 资源中检索的描述毒液化合物对哺乳动物解剖结构影响的记录。来自 VenomKB 的数据可以以多种流行的数据格式有选择地检索，是开源的，并将随着毒液疗法的进一步理解而不断更新。
