Li Wan-Fei, Wang Juan, Zhang Jing-Jie, Song Xun, Ku Chuen-Fai, Zou Juan, Li Ji-Xin, Rong Li-Jun, Pan Lu-Tai, Zhang Hong-Jie
Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China.
School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong, China.
Int J Mol Sci. 2015 Nov 24;16(11):27978-87. doi: 10.3390/ijms161126071.
Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).
从亨利凤尾蕨的叶子中分离出一种新的对映-贝壳杉烷二萜——亨利烷A(1)。通过分析包括一维(1D)和二维(2D)核磁共振谱在内的光谱数据阐明了其化学结构，并通过X射线晶体学分析进一步证实。对该化合物针对一组癌细胞系、牙菌斑生物膜形成和HIV的生物活性进行了评估。它显示出抗HIV潜力，IC50值为9.1µM(SI = 12.2)。
