Gurgul A, Szmatoła T, Ropka-Molik K, Jasielczuk I, Pawlina K, Semik E, Bugno-Poniewierska M
Laboratory of Genomics, Department of Animal Genomics and Molecular Biology, National Research Institute of Animal Production, Balice, Poland.
J Anim Breed Genet. 2016 Aug;133(4):264-76. doi: 10.1111/jbg.12196. Epub 2015 Nov 26.
The study is aimed at identifying selection footprints within the genome of Limousin cattle. With the use of Extended Haplotype Homozygosity test, supplemented with correction for variation in recombination rates across the genome, we created map of selection footprints and detected 173 significant (p < 0.01) core haplotypes being potentially under positive selection. Within these regions, a number of candidate genes associated inter alia with skeletal muscle growth (GDF15, BMP7, BMP4 and TGFB3) or postmortem proteolysis and meat maturation (CAPN1 and CAPN5) were annotated. Noticeable clusters of selection footprints were detected on chromosomes 1, 4, 8 and 14, which are known to carry several quantitative trait loci for growth traits and meat quality. The study provides information about the genes and metabolic pathways potentially modified under the influence of directional selection, aimed at improving beef production characteristics in Limousin cattle.
该研究旨在识别利木赞牛基因组中的选择印记。通过使用扩展单倍型纯合性测试，并辅以对全基因组重组率变化的校正，我们创建了选择印记图谱，并检测到173个显著（p < 0.01）的核心单倍型可能处于正选择之下。在这些区域内，注释了一些候选基因，这些基因尤其与骨骼肌生长（GDF15、BMP7、BMP4和TGFB3）或宰后蛋白水解和肉成熟（CAPN1和CAPN5）相关。在1号、4号、8号和14号染色体上检测到明显的选择印记簇，这些染色体已知携带多个与生长性状和肉质相关的数量性状基因座。该研究提供了有关在定向选择影响下可能发生改变的基因和代谢途径的信息，旨在改善利木赞牛的牛肉生产特性。
