微小RNA在睾丸癌诊断和预后中的作用

MicroRNAs in Testicular Cancer Diagnosis and Prognosis.

作者信息

Ling Hui, Krassnig Lisa, Bullock Marc D, Pichler Martin

机构信息

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA.

Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria.

出版信息

Urol Clin North Am. 2016 Feb;43(1):127-34. doi: 10.1016/j.ucl.2015.08.013.

DOI:10.1016/j.ucl.2015.08.013

PMID:26614035

Abstract

Testicular cancer processes a unique and clear miRNA expression signature. This differentiates testicular cancer from most other cancer types, which are usually more ambiguous when assigning miRNA patterns. As such, testicular cancer may represent a unique cancer type in which miRNAs find their use as biomarkers for cancer diagnosis and prognosis, with a potential to surpass the current available markers usually with low sensitivity. In this review, we present literature findings on miRNAs associated with testicular cancer, and discuss their potential diagnostic and prognostic values, as well as their potential as indicators of drug response in patients with testicular cancer.

摘要

睾丸癌具有独特且清晰的微小RNA（miRNA）表达特征。这使得睾丸癌与大多数其他癌症类型有所区别，其他癌症类型在确定miRNA模式时通常更为模糊。因此，睾丸癌可能代表一种独特的癌症类型，在其中miRNA可作为癌症诊断和预后的生物标志物，并且有可能超越目前通常敏感性较低的现有标志物。在本综述中，我们展示了与睾丸癌相关的miRNA的文献研究结果，并讨论了它们潜在的诊断和预后价值，以及它们作为睾丸癌患者药物反应指标的潜力。