Department of Stomatology, Division of Periodontics, University of São Paulo, São Paulo, Brazil; Department and Institute of Psychiatry, University of São Paulo, São Paulo, Brazil.
Department and Institute of Psychiatry, University of São Paulo, São Paulo, Brazil.
Brain Behav Immun. 2016 Mar;53:49-53. doi: 10.1016/j.bbi.2015.11.014. Epub 2015 Nov 23.
An imbalance in stimulated cytokine production is associated with the etiopathogenesis of numerous diseases such as major depressive disorder (MDD) and periodontal disease. Increased cytokine levels have been reported in the gingival crevicular fluid (GCF) of patients with MDD. Thirty-six outpatients with MDD participated in this study. Each outpatient was age-matched (± 3 years) with a healthy control (n=36). The patients were controlled for race and smoking habits. Unstimulated and stimulated interleukin 6 (IL-6), interleukin 1β (IL-1β), and interferon-γ (INF-γ) production in whole blood culture (WBC) and IL-6 and IL-1β levels in the GCF were evaluated. Circulating levels of IL-6 and IL-1β (unstimulated) as well as GCF IL-1β were modestly lower in MDD patients, compared to the levels in age-matched controls (Mann-Whitney, p=0.002, 0.0075, ANCOVA, p=0.025, respectively). In the unstimulated group, there was no correlation between the levels of circulating IL-6 and GCF IL-6 (r=0.07, p=0.67), and between the levels of circulating IL-1β and the IL-1β level in the CGF (r=-0.08, p=0.63). In the LPS stimulation group, there was no correlation between the levels of circulating levels of IL-6 and GCF IL-6 (r=0. 02, p=0.91) or between the circulating IL-1β and GCF IL-1β (r=0.13, p=0.42). We observed modest immunosuppression in MDD patients (evaluated by no stimulation whole blood culture [WBC]), especially in patients with melancholic depression, chronic depression, and severe depression.
细胞因子产生失衡与许多疾病的病因发病机制有关，如重度抑郁症（MDD）和牙周病。有报道称，MDD 患者的龈沟液（GCF）中细胞因子水平升高。本研究纳入 36 名 MDD 门诊患者。每位患者均与年龄匹配的健康对照者（n=36）进行匹配。对患者进行种族和吸烟习惯的匹配。评估全血培养（WBC）中未刺激和刺激的白细胞介素 6（IL-6）、白细胞介素 1β（IL-1β）和干扰素-γ（INF-γ）产生情况以及 GCF 中的 IL-6 和 IL-1β 水平。与年龄匹配的对照组相比，MDD 患者的循环 IL-6 和 IL-1β（未刺激）以及 GCF IL-1β 水平略低（Mann-Whitney，p=0.002，0.0075，ANCOVA，p=0.025）。在未刺激组中，循环 IL-6 与 GCF IL-6 水平之间无相关性（r=0.07，p=0.67），循环 IL-1β 与 GCF IL-1β 水平之间也无相关性（r=-0.08，p=0.63）。在 LPS 刺激组中，循环 IL-6 与 GCF IL-6 水平之间无相关性（r=0.02，p=0.91），循环 IL-1β 与 GCF IL-1β 水平之间也无相关性（r=0.13，p=0.42）。我们观察到 MDD 患者存在适度的免疫抑制（通过未刺激的全血培养[WBC]评估），尤其是在患有忧郁性抑郁症、慢性抑郁症和重度抑郁症的患者中。
