Wei Jian-Ming, Zhang Zi-Zhen, Shen Yan-Ying, Shen Dan-Ping, Ni Xing-Zhi
Department of General Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China.
Oncol Lett. 2015 Sep;10(3):1251-1254. doi: 10.3892/ol.2015.3465. Epub 2015 Jul 8.
Gastric neuroendocrine carcinoma (G-NEC) is a rare neoplasm known for its aggressive behavior and poor prognosis. Brunner's gland adenoma (BGA) is a rare benign proliferative lesion that develops most commonly in the duodenum. To the best of our knowledge, no cases of G-NEC coexisting with BGA have previously been reported. The present study therefore reports the first case of G-NEC combined with BGA. A 67-year-old female presented with upper abdominal discomfort. No distant metastases were detected upon pre-operative abdominal computed tomography imaging. The patient underwent a radical distal gastrectomy, D2 lymphadenectomy and Billroth I gastroenterostomy. The resected masses were histologically confirmed to be G-NEC and BGA, respectively. The patient did not receive neoadjuvant or adjuvant chemotherapy or radiotherapy, and remains alive with no evidence of metastasis or recurrence at four years post-surgery.
胃神经内分泌癌（G-NEC）是一种罕见的肿瘤，以其侵袭性生长行为和不良预后而闻名。布伦纳腺腺瘤（BGA）是一种罕见的良性增生性病变，最常发生于十二指肠。据我们所知，此前尚无G-NEC与BGA并存的病例报道。因此，本研究报告了首例G-NEC合并BGA的病例。一名67岁女性因上腹部不适就诊。术前腹部计算机断层扫描成像未发现远处转移。患者接受了根治性远端胃切除术、D2淋巴结清扫术和毕罗一式胃肠吻合术。切除的肿块经组织学检查分别确诊为G-NEC和BGA。患者未接受新辅助或辅助化疗及放疗，术后四年仍存活，无转移或复发迹象。
