Nime Md Julkar, Yamamura Hideki, Hayakawa Masayuki, Matsuura Nobuyasu, Oku Naoya, Igarashi Yasuhiro
Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.
Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, Japan.
J Antibiot (Tokyo). 2025 Feb;78(3):141-148. doi: 10.1038/s41429-024-00794-4. Epub 2025 Jan 6.
Two new benzene-containing polyketides, cryptoic acids A (1) and B (2), along with a new acylated diketopiperazine designated cyclocryptamide (3), were isolated from the culture extract of Cryptosporangium sp. YDKA-T02. The absolute configuration of amino acid components in 3 was determined by Marfey's method. While 3 was not cytotoxic and inactive against microbial test strains, 1 and 2 showed PPARγ agonistic activity in a reporter gene assay and cytotoxicity against P388 murine leukemia cells.
从隐孢囊菌属YDKA-T02的培养提取物中分离出两种新的含苯聚酮化合物，隐孢酸A（1）和B（2），以及一种新的酰化二酮哌嗪，命名为环隐酰胺（3）。采用马尔菲法确定了3中氨基酸成分的绝对构型。虽然3没有细胞毒性且对微生物测试菌株无活性，但1和2在报告基因检测中显示出PPARγ激动活性，并对P388小鼠白血病细胞具有细胞毒性。
