阿格拉宾的化学修饰及其新衍生物的生物活性

Chemical modification of arglabin and biological activity of its new derivatives.

作者信息

Adekenov S M

机构信息

International Research and Production Holding "Phytochemistry", Karaganda 100009, Kazakhstan.

出版信息

Fitoterapia. 2016 Apr;110:196-205. doi: 10.1016/j.fitote.2015.11.018. Epub 2015 Nov 25.

DOI:10.1016/j.fitote.2015.11.018

PMID:26625839

Abstract

This review summarizes the results of own research on chemical modification of the molecule of sesquiterpene lactone arglabin from Artemisia glabella Kar. et Kir. Over 70 new arglabin derivatives were obtained which are polyfunctional compounds with oxy functions, atoms of haloids, phosphorus, nitrogen, and cyclopropane fragments. For the first time the results of bioscreening of new arglabin derivatives are reported.

摘要

本综述总结了对来自光滑蒿（Artemisia glabella Kar. et Kir.）的倍半萜内酯阿拉宾分子进行化学修饰的自身研究结果。获得了70多种新的阿拉宾衍生物，它们是具有氧官能团、卤素原子、磷、氮和环丙烷片段的多官能化合物。首次报道了新阿拉宾衍生物的生物筛选结果。