Liao Ning, Chen Min-Li, Zhao Hua, Xie Zheng-Fu
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University Nanning, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):14916-25. eCollection 2015.
There is no consensus regarding the association between polymorphisms in the myosin IXB (MYO9B) gene and celiac disease (CD) risk. In this study, we performed a meta-analysis to evaluate genetic variants in MYO9B with CD.
Four MYO9B polymorphisms (rs1545620, rs1457092, rs2305767 and rs2305764) were assessed. A literature search was conducted using PubMed, Scopus, and Web of Science databases until June 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to investigate the strength of the association under dominant, recessive, homozygote and allelic comparison models.
Seven case-control studies with a total of 1965 CD patients and 4894 controls were included in this meta-analysis. The results showed that rs1545620 was associated with CD risk in Europeans in dominant (OR=1.31, 95% CI: 1.10-1.58, Pz =0.003), recessive (OR=1.36, 95% CI: 1.08-1.72, Pz =0.009), homozygote (OR=1.55, 95% CI: 1.20-2.01, Pz =0.001), and allelic comparison models (OR=1.24, 95% CI: 1.10-1.40, Pz =0.001), whereas in a Latin American group there were significant associations of CD with rs1457092 in dominant (OR=15.30, 95% CI: 3.51-66.67, Pz <0.001), homozygote (OR=16.55, 95% CI: 3.62-75.65, Pz <0.001), and allelic comparison models (OR=1.95, 95% CI: 1.31-2.91, Pz =0.001), and rs2305767 in dominant (OR=5.35, 95% CI: 2.42-11.86, Pz <0.001) and allelic comparison models (OR=1.65, 95% CI: 1.11-2.45, Pz =0.013). There was no association between rs2305764 and CD risk in either Europeans or the Latin American group.
rs1545620 is associated with CD risk in Europeans, whereas rs1457092 and rs2305767 are associated with CD risk in a Latin American group.
关于肌球蛋白IXB（MYO9B）基因多态性与乳糜泻（CD）风险之间的关联尚无共识。在本研究中，我们进行了一项荟萃分析，以评估MYO9B基因变异与CD的关系。
评估了四个MYO9B多态性（rs1545620、rs1457092、rs2305767和rs2305764）。使用PubMed、Scopus和Web of Science数据库进行文献检索，直至2015年6月。比值比（OR）和95%置信区间（CI）用于在显性、隐性、纯合子和等位基因比较模型下研究关联强度。
本荟萃分析纳入了7项病例对照研究，共1965例CD患者和4894例对照。结果显示，rs1545620在欧洲人中与CD风险相关，在显性（OR = 1.31，95% CI：1.10 - 1.58，P = 0.003）、隐性（OR = 1.36，95% CI：1.08 - 1.72，P = 0.009）、纯合子（OR = 1.55，95% CI：1.20 - 2.01，P = 0.001）和等位基因比较模型（OR = 1.24，95% CI：1.10 - 1.40，P = 0.001）中均有相关性；而在拉丁美洲人群中，rs1457092在显性（OR = 15.30，95% CI：3.51 - 66.67，P < 0.001）、纯合子（OR = 16.55，95% CI：3.62 - 75.65，P < 0.001）和等位基因比较模型（OR = 1.95，95% CI：1.31 - 2.91，P = 0.001）中与CD风险显著相关，rs2305767在显性（OR = 5.35，95% CI：2.42 - 11.86，P < 0.001）和等位基因比较模型（OR = 1.65，95% CI：1.11 - 2.45，P = 0.013）中与CD风险相关。rs2305764在欧洲人和拉丁美洲人群中均与CD风险无关。
rs1545620与欧洲人的CD风险相关，而rs1457092和rs2305767与拉丁美洲人群的CD风险相关。
