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本文引用的文献

1
miR-143 inhibits NSCLC cell growth and metastasis by targeting Limk1.微小RNA-143通过靶向Limk1抑制非小细胞肺癌细胞的生长和转移。
Int J Mol Sci. 2014 Jul 7;15(7):11973-83. doi: 10.3390/ijms150711973.
2
Colorectal cancer statistics, 2014.结直肠癌统计数据，2014 年。
CA Cancer J Clin. 2014 Mar-Apr;64(2):104-17. doi: 10.3322/caac.21220. Epub 2014 Mar 17.
3
Current Understanding on EGFR and Wnt/β-Catenin Signaling in Glioma and Their Possible Crosstalk.当前对胶质瘤中表皮生长因子受体（EGFR）和Wnt/β-连环蛋白信号通路的认识及其可能的相互作用
Genes Cancer. 2013 Nov;4(11-12):427-46. doi: 10.1177/1947601913503341.
4
Changes in miR-143 and miR-21 expression and clinicopathological correlations in pancreatic cancers.胰腺癌细胞中 miR-143 和 miR-21 表达的变化及其与临床病理的相关性。
Pancreas. 2012 Nov;41(8):1280-4. doi: 10.1097/MPA.0b013e31824c11f4.
5
miR-143, miR-222, and miR-452 are useful as tumor stratification and noninvasive diagnostic biomarkers for bladder cancer.miR-143、miR-222 和 miR-452 可用作膀胱癌的肿瘤分层和非侵入性诊断生物标志物。
Am J Pathol. 2012 May;180(5):1808-15. doi: 10.1016/j.ajpath.2012.01.034. Epub 2012 Mar 15.
6
Expression of mir-21 and mir-143 in cervical specimens ranging from histologically normal through to invasive cervical cancer.miR-21 和 miR-143 在组织学正常至浸润性宫颈癌宫颈标本中的表达。
PLoS One. 2011;6(12):e28423. doi: 10.1371/journal.pone.0028423. Epub 2011 Dec 14.
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MicroRNAs in the pathogenesis of cancer.微小 RNA 在癌症发病机制中的作用。
Semin Oncol. 2011 Dec;38(6):724-33. doi: 10.1053/j.seminoncol.2011.08.006.
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Inducible expression of TGFβ, snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC model.TGFβ、snail 和 Zeb1 的诱导表达在 NSCLC 模型中体外和体内重现 EMT。
Clin Exp Metastasis. 2011 Oct;28(7):593-614. doi: 10.1007/s10585-011-9394-8. Epub 2011 Jun 4.
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CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer.CCN6（WISP3）通过衰减 IGF-1 受体信号转导降低乳腺癌中的 ZEB1 介导的 EMT 和侵袭。
J Cell Sci. 2011 May 15;124(Pt 10):1752-8. doi: 10.1242/jcs.084194. Epub 2011 Apr 26.
10
MiRNA profile in esophageal squamous cell carcinoma: downregulation of miR-143 and miR-145.食管鳞状细胞癌中的 miRNA 谱：miR-143 和 miR-145 的下调。
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微小RNA-143调节结肠癌细胞的增殖和凋亡，并在结直肠癌组织中呈现表达改变。

miR-143 regulates proliferation and apoptosis of colorectal cancer cells and exhibits altered expression in colorectal cancer tissue.

作者信息

Yang Fan, Xie Yi-Qiang, Tang Song-Qi, Wu Xian-Bo, Zhu Hai-Yan

机构信息

College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine Tianjin 300193, Tianjin Province, P. R. China.

Department of Traditional Chinese Medicine, Hainan Medical University Haikou 571199, Hainan Province, P. R. China.

出版信息

Int J Clin Exp Med. 2015 Sep 15;8(9):15308-12. eCollection 2015.

PMID:26629019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4658908/
Abstract

Colorectal cancer is one of the most commonly diagnosed cancers and a leading cause of death. Studies have shown that abnormal expression of microRNAs, small non-coding RNA molecules that regulate gene expression, is linked to the occurrence of cancer. This study sought to determine the role of microRNA-143 (miR-143) in colorectal cancer. Reduced levels of miR-143 expression were detected in colorectal cancer tissues compared to normal adjacent tissue. Transfection of artificially synthesized miR-143 mimics into SW-480 cells, a colorectal cancer cell line, resulted in increased levels of cell proliferation and apoptosis. Further, cells transfected with miR-143 mimics showed a reduction in the proportion of cells in S phase and an increase in the proportion of cells in G1 phase. The altered expression levels of miR-143 in colorectal cancer and its ability to affect the behavior of colorectal cancer cells suggest miR-143 could be used as a new target for the diagnosis and treatment of colorectal cancer.

摘要

结直肠癌是最常被诊断出的癌症之一，也是主要的死亡原因。研究表明，微小RNA（miRNA）是一类调控基因表达的小型非编码RNA分子，其异常表达与癌症的发生有关。本研究旨在确定微小RNA-143（miR-143）在结直肠癌中的作用。与相邻正常组织相比，在结直肠癌组织中检测到miR-143表达水平降低。将人工合成的miR-143模拟物转染到结直肠癌细胞系SW-480细胞中，导致细胞增殖和凋亡水平增加。此外，用miR-143模拟物转染的细胞显示S期细胞比例降低，G1期细胞比例增加。miR-143在结直肠癌中的表达水平改变及其影响结直肠癌细胞行为的能力表明，miR-143可作为结直肠癌诊断和治疗的新靶点。