Javed Zeeshan, Javed Iqbal Muhammad, Rasheed Amna, Sadia Haleema, Raza Shahid, Irshad Asma, Koch Wojciech, Kukula-Koch Wirginia, Głowniak-Lipa Anna, Cho William C, Sharifi-Rad Javad
Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan.
Department of Biotechnology, Faculty of Sciences, University of Sialkot, Sialkot, Pakistan.
Front Oncol. 2021 Jan 7;10:607607. doi: 10.3389/fonc.2020.607607. eCollection 2020.
Hedgehog (Hh) signaling aberrations trigger differentiation and proliferation in colorectal cancer (CRC). However, the current approaches which inhibit this vital cellular pathway provoke some side effects. Therefore, it is necessary to look for new therapeutic options. MicroRNAs are small molecules that modulate expression of the target genes and can be utilized as a potential therapeutic option for CRC. On the other hand, nanoformulations have been implemented in the treatment of plethora of diseases. Owing to their excessive bioavailability, limited cytotoxicity and high specificity, nanoparticles may be considered as an alternative drug delivery platform for the Hh signaling mediated CRC. This article reviews the Hh signaling and its involvement in CRC with focus on miRNAs, nanoformulations as potential diagnostic/prognostic and therapeutics for CRC.
刺猬信号通路（Hh）异常激活会引发结直肠癌（CRC）的分化和增殖。然而，目前抑制这一重要细胞通路的方法会引发一些副作用。因此，有必要寻找新的治疗方案。微小RNA是一类可调节靶基因表达的小分子，有望成为CRC的潜在治疗手段。另一方面，纳米制剂已被应用于多种疾病的治疗。由于纳米颗粒具有高生物利用度、低细胞毒性和高特异性等优点，可被视为Hh信号通路介导的CRC的替代药物递送平台。本文综述了Hh信号通路及其在CRC中的作用，重点讨论了微小RNA、纳米制剂作为CRC潜在诊断/预后指标及治疗手段的研究进展。
