Bao Xiao-Yuan, Xu Bei-Bei, Fang Kai, Li Yan, Hu Yong-Hua, Yu Guo-Pei
Medical Informatics Center , Peking University , Beijing , China.
Department of Epidemiology , School of Public Health, Peking University , Beijing , China.
BMJ Open Gastroenterol. 2015 Aug 27;2(1):e000051. doi: 10.1136/bmjgast-2015-000051. eCollection 2015.
To examine if the hospitalisation trends of liver cirrhosis are changing with the changes of risk factors of the disease in China.
Secondary analysis of hospitalisation records in the 31 top-ranking hospitals in Beijing.
Between 2006 and 2010, hospitalisation from viral hepatitis cirrhosis (VHC) decreased by 10% (95% CI=5-14%, p<0.001), but non-viral hepatitis cirrhosis (NVHC) and alcoholic cirrhosis (AC) increased by 35% (26-46%, p<0.001) and 33% (19%- 47%, p<0.001), respectively. The age patterns of hospitalisation varied with different types of liver cirrhosis. The hospitalisation risks for patients with VHC and AC were significantly high in the age groups 40-49 and 50-59 years, but risks for those with NHVC were high in all age groups of 40 years or above. Overall male-to-female hospitalisation ratios for VHC, NVHC and AC were 2.71, 1.14 and 59.9, respectively. The sex ratio became smaller with time from 2006 to 2010 in hospitalised patients with VHC, but it substantially increased in those with NVHC during the same period.
Hospitalisation rates for liver cirrhosis in Beijing are changing with time. The changes of viral hepatitis infection and alcohol consumption in the general population may cause these changes.
探讨在中国肝硬化的住院趋势是否随疾病危险因素的变化而改变。
对北京31家顶级医院的住院记录进行二次分析。
2006年至2010年期间，病毒性肝炎肝硬化（VHC）的住院率下降了10%（95%置信区间=5-14%，p<0.001），但非病毒性肝炎肝硬化（NVHC）和酒精性肝硬化（AC）分别上升了35%（26-46%，p<0.001）和33%（19%-47%，p<0.001）。不同类型肝硬化的住院年龄模式有所不同。VHC和AC患者在40-49岁和50-59岁年龄组的住院风险显著较高，但NHVC患者在40岁及以上的所有年龄组住院风险都较高。VHC、NVHC和AC的总体男女住院比例分别为2.71、1.14和59.9。2006年至2010年期间，VHC住院患者的性别比随时间变小，但同期NVHC住院患者的性别比大幅上升。
北京肝硬化的住院率随时间变化。普通人群中病毒性肝炎感染和酒精消费的变化可能导致了这些变化。
