Al-Daihan Sooad, Shafi Bhat Ramesa
Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia.
Int J Mol Cell Med. 2015 Summer;4(3):188-95.
Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific markers such as aspartate transaminase, alanine transaminase, and alkaline phosphatase were estimated. Antioxidant status in liver tissues was estimated by determining the level of lipid peroxidation and activities of enzymatic and non-enzymatic antioxidants. Sodium and potassium levels were also measured in liver tissue. PA treatment caused significant changes in all hepatospecific markers. Biochemical analysis of liver homogenates from PA-treated rats showed an increase in oxidative stress markers like lipid peroxidation and lactate dehydrogenase, coupled with a decrease in glutathione, vitamin C and glutathione S- transferase. However, PA exposure caused no change in sodium and potassium levels in liver tissue. Our study demonstrated that PA persuade hepatic damage in rats.
丙酸（PA）是一种短链脂肪酸，是一种常见的食品防腐剂，也是肠道中肠道细菌的代谢终产物。本研究旨在探讨PA对雄性大鼠肝损伤的影响。雄性西方白化大鼠被分为两组。第一组作为正常对照组，第二组用PA处理。测定了血清肝特异性标志物如天冬氨酸转氨酶、丙氨酸转氨酶和碱性磷酸酶的活性。通过测定脂质过氧化水平以及酶促和非酶促抗氧化剂的活性来评估肝组织中的抗氧化状态。还测量了肝组织中的钠和钾水平。PA处理导致所有肝特异性标志物发生显著变化。对PA处理大鼠的肝脏匀浆进行生化分析显示，脂质过氧化和乳酸脱氢酶等氧化应激标志物增加，同时谷胱甘肽、维生素C和谷胱甘肽S-转移酶减少。然而，PA暴露并未导致肝组织中钠和钾水平发生变化。我们的研究表明，PA会导致大鼠肝脏损伤。
