Hirano T, Miyajima H, Kaziwara K, Watanabe T
Acta Pathol Jpn. 1977 Mar;27(2):145-64. doi: 10.1111/j.1440-1827.1977.tb01866.x.
Moloney murine sarcoma virus (M-MSV) was injected directly into the fetuses of Sprague-Dawley rats during the late stage of gestation and into the neonates within 24 hours after birth. Ninety rats developed 188 neoplastic lesions during the 8-week period of observation. Nearly all of the neoplasms were of mesenchymal derivation. Sixty percent of these neoplasms revealed more complex histologic features than those previously reported for neoplasms induced in rodents with M-MSV and were designated "malignant mesenchymoma" which developed preferentially in the proximal parts of the extremities, distant from the inoculation site. Rhabdomyosarcoma and osteosarcoma which developed in a pure form at the various sites were the next most common tumor type. Osteosarcoma developing in a pure form and as a component of malignant mesenchymoma in the humerus and femur was comparable to that of juxtacortical osteosarcoma of man; The development of excessive bones were observed in the forelimb and/or hind leg, suggesting a type of skeletal malformation. The reaction to M-MSV merits attention as a model for the study of an osteosarcoma and malignant mesenchymoma as well as rhabdomyosarcoma and also for the study of viral teratogenesis in man, as "rubella syndrome".
在妊娠后期，将莫洛尼鼠肉瘤病毒（M-MSV）直接注射到斯普拉格-道利大鼠的胎儿体内，并在出生后24小时内注射到新生大鼠体内。在8周的观察期内，90只大鼠出现了188个肿瘤性病变。几乎所有肿瘤均来源于间充质。这些肿瘤中有60%表现出比先前报道的用M-MSV诱导的啮齿动物肿瘤更复杂的组织学特征，被命名为“恶性间叶瘤”，其优先发生在四肢近端，远离接种部位。在不同部位以纯形式出现的横纹肌肉瘤和骨肉瘤是次常见的肿瘤类型。在肱骨和股骨中以纯形式以及作为恶性间叶瘤的一个组成部分出现的骨肉瘤与人类皮质旁骨肉瘤相似；在前肢和/或后肢观察到骨骼过度生长，提示一种骨骼畸形。M-MSV的反应作为研究骨肉瘤、恶性间叶瘤以及横纹肌肉瘤的模型，以及作为研究人类病毒致畸作用（如“风疹综合征”）值得关注。
