有或没有可能的轻度认知障碍的老年人的皮质听觉诱发反应。

Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment.

作者信息

Lister Jennifer J, Harrison Bush Aryn L, Andel Ross, Matthews Courtney, Morgan David, Edwards Jerri D

机构信息

Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.

出版信息

Clin Neurophysiol. 2016 Feb;127(2):1279-1287. doi: 10.1016/j.clinph.2015.11.007. Epub 2015 Nov 19.

DOI:10.1016/j.clinph.2015.11.007

PMID:26643153

Abstract

OBJECTIVE

Hearing loss has been well-documented as a risk factor for cognitive impairment, but the simple presence of hearing loss is not a sufficient predictor of cognitive decline. Although auditory behavioral research has not revealed an effective indicator of early cognitive impairment, a limited number of studies using cortical auditory evoked potentials (CAEPs) have shown promising evidence of an auditory neurophysiological indicator of early-stage cognitive impairment. The purpose of this study was to examine the P1-N1-P2 complex for indicators of cognitive impairment.

METHODS

The latency and amplitude of the P1-N1-P2 complex was measured for two stimuli (pure tone, speech) in two groups: cognitively normal older adults (CNOAs) and older adults with probable mild cognitive impairment (MCI), based on the Montreal Cognitive Assessment.

RESULTS

Significantly smaller P2 amplitudes were found for those with probable MCI compared to CNOA across stimulus conditions. Stimulus effects were found for P1 and P2 latency.

CONCLUSION

P2 amplitude may be a useful indicator of early-stage cognitive impairment.

SIGNIFICANCE

As effective treatments become available, early identification of cognitive impairment can facilitate the prescription of treatment at the earliest juncture. CAEPs have the potential to serve as efficient, non-invasive, cost-effective indicators of future cognitive decline and impairment.

摘要

目的

听力损失作为认知障碍的一个风险因素已有充分记录，但单纯的听力损失并非认知能力下降的充分预测指标。尽管听觉行为研究尚未揭示早期认知障碍的有效指标，但少数使用皮质听觉诱发电位（CAEPs）的研究已显示出关于早期认知障碍的听觉神经生理学指标的有前景的证据。本研究的目的是检查P1-N1-P2复合波以寻找认知障碍的指标。