Lister Jennifer J, Harrison Bush Aryn L, Andel Ross, Matthews Courtney, Morgan David, Edwards Jerri D
Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Department of Communication Sciences and Disorders, University of South Florida, Tampa, FL, USA; School of Aging Studies, University of South Florida, Tampa, FL, USA; USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
Clin Neurophysiol. 2016 Feb;127(2):1279-1287. doi: 10.1016/j.clinph.2015.11.007. Epub 2015 Nov 19.
Hearing loss has been well-documented as a risk factor for cognitive impairment, but the simple presence of hearing loss is not a sufficient predictor of cognitive decline. Although auditory behavioral research has not revealed an effective indicator of early cognitive impairment, a limited number of studies using cortical auditory evoked potentials (CAEPs) have shown promising evidence of an auditory neurophysiological indicator of early-stage cognitive impairment. The purpose of this study was to examine the P1-N1-P2 complex for indicators of cognitive impairment.
The latency and amplitude of the P1-N1-P2 complex was measured for two stimuli (pure tone, speech) in two groups: cognitively normal older adults (CNOAs) and older adults with probable mild cognitive impairment (MCI), based on the Montreal Cognitive Assessment.
Significantly smaller P2 amplitudes were found for those with probable MCI compared to CNOA across stimulus conditions. Stimulus effects were found for P1 and P2 latency.
P2 amplitude may be a useful indicator of early-stage cognitive impairment.
As effective treatments become available, early identification of cognitive impairment can facilitate the prescription of treatment at the earliest juncture. CAEPs have the potential to serve as efficient, non-invasive, cost-effective indicators of future cognitive decline and impairment.
听力损失作为认知障碍的一个风险因素已有充分记录，但单纯的听力损失并非认知能力下降的充分预测指标。尽管听觉行为研究尚未揭示早期认知障碍的有效指标，但少数使用皮质听觉诱发电位（CAEPs）的研究已显示出关于早期认知障碍的听觉神经生理学指标的有前景的证据。本研究的目的是检查P1-N1-P2复合波以寻找认知障碍的指标。
基于蒙特利尔认知评估，对两组人群（认知正常的老年人（CNOAs）和可能患有轻度认知障碍（MCI）的老年人）的两种刺激（纯音、言语）测量P1-N1-P2复合波的潜伏期和波幅。
在所有刺激条件下，与CNOA相比，可能患有MCI的人群的P2波幅明显更小。在P1和P2潜伏期发现了刺激效应。
P2波幅可能是早期认知障碍的一个有用指标。
随着有效治疗方法的出现，早期识别认知障碍可有助于尽早开出治疗处方。CAEPs有潜力作为未来认知能力下降和障碍的有效、非侵入性且具有成本效益的指标。
