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中枢神经系统和肠神经系统在逆行性巨收缩控制中的作用。

The Role of Central and Enteric Nervous Systems in the Control of the Retrograde Giant Contraction.

作者信息

Lang Ivan M

机构信息

Dysphagia Animal Research Laboratory, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.

出版信息

J Neurogastroenterol Motil. 2016 Apr 30;22(2):321-32. doi: 10.5056/jnm15141.

DOI:10.5056/jnm15141
PMID:26645249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4819871/
Abstract

BACKGROUND/AIMS: The role of the enteric (ENS) and central (CNS) nervous systems in the control of the retrograde giant contraction (RGC) associated with vomiting is unknown.

METHODS

The effects of myotomy or mesenteric nerve transection (MNT) on apomorphine-induced emesis were investigated in 18 chronically instrumented dogs.

RESULTS

Neither surgery affected the RGC orad of the surgical site or the velocity of the RGC over the entire small intestine. Myotomy blocked the RGC for 17 ± 5 cm aborad of the myotomy, and the velocity of the RGC from 100 to 70 cm from the pylorus slowed (18.1 ± 3.0 to 9.0 ± 0.8 cm/sec) such that the RGC orad and aborad of the myotomy occurred simultaneously. After MNT, the RGC was unchanged up to 66 ± 6 cm from the pylorus, and the sequence of the RGC across the denervated intestine was unaltered. The velocity of the RGC from 100 to 70 cm from the pylorus increased from 12.8 ± 1.6 to 196 ± 116 cm/sec. After myotomy or MNT, the percent occurrence and magnitude of the RGC across the intestine 100 to 70 cm from the pylorus decreased.

CONCLUSIONS

The CNS activates the RGC 10 to 20 cm aborad of its innervation of the intestine and controls the RGC sequence. On the other hand, the ENS plays a role in initiation and generation of the RGC.

摘要

背景/目的：肠神经系统（ENS）和中枢神经系统（CNS）在控制与呕吐相关的逆行性巨收缩（RGC）中的作用尚不清楚。

方法

在18只长期植入仪器的犬中研究了肌切开术或肠系膜神经切断术（MNT）对阿扑吗啡诱导呕吐的影响。

结果

两种手术均未影响手术部位口侧的RGC或整个小肠的RGC速度。肌切开术在肌切开术肛侧17±5 cm处阻断了RGC，并且从幽门100至70 cm处的RGC速度减慢（从18.1±3.0降至9.0±0.8 cm/秒），使得肌切开术口侧和肛侧的RGC同时发生。MNT后，距幽门66±6 cm以内的RGC未改变，并且去神经支配肠段的RGC顺序未改变。从幽门100至70 cm处的RGC速度从12.8±1.6增加至196±116 cm/秒。肌切开术或MNT后，距幽门100至70 cm肠段的RGC发生率和幅度百分比降低。

结论

CNS在其对肠的神经支配肛侧10至20 cm处激活RGC并控制RGC顺序。另一方面，ENS在RGC的起始和产生中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/bf3974e2e70c/jnm-22-321f14.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/78555f114e46/jnm-22-321f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/bf3974e2e70c/jnm-22-321f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/47bb2f27c9a9/jnm-22-321f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/62a493f9920d/jnm-22-321f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/003753aa48fd/jnm-22-321f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/17b9c737cc4c/jnm-22-321f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/16f49d481acb/jnm-22-321f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/78555f114e46/jnm-22-321f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/96d1af8f521f/jnm-22-321f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/a11cbe686b1e/jnm-22-321f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/9d3342b6f1a8/jnm-22-321f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/3241650183b4/jnm-22-321f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/e4a987252ede/jnm-22-321f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/346b/4819871/bf3974e2e70c/jnm-22-321f14.jpg

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本文引用的文献

1
The significance of interstitial cells in neurogastroenterology.神经胃肠病学中间质细胞的意义。
J Neurogastroenterol Motil. 2014 Jul 31;20(3):294-317. doi: 10.5056/jnm14060.
2
Functional localization of central coordinating mechanism for emesis in cat.猫呕吐中枢协调机制的功能定位
J Neurophysiol. 1949 Sep;12(5):305-13. doi: 10.1152/jn.1949.12.5.305.
3
Changes in intestinal tone and motility associated with nausea and vomiting.与恶心和呕吐相关的肠道张力和蠕动变化。
阿马林对分离的大鼠胃窦和门静脉平滑肌条收缩模式的影响及其对胃底神经源性松弛的作用。
Pflugers Arch. 2019 Jul;471(7):995-1005. doi: 10.1007/s00424-019-02279-y. Epub 2019 May 2.
4
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.治疗恶心和呕吐的药物发现史及其对未来研究的启示
Front Pharmacol. 2018 Sep 4;9:913. doi: 10.3389/fphar.2018.00913. eCollection 2018.
5
What is nausea? A historical analysis of changing views.什么是恶心？对观点演变的历史分析。
Auton Neurosci. 2017 Jan;202:5-17. doi: 10.1016/j.autneu.2016.07.003. Epub 2016 Jul 16.
J Physiol. 1946 Jul 15;105(1):58-65.
4
Classes of enteric nerve cells in the guinea-pig small intestine.豚鼠小肠中肠神经细胞的类别。
Anat Rec. 2001 Jan 1;262(1):58-70. doi: 10.1002/1097-0185(20010101)262:1<58::AID-AR1011>3.0.CO;2-V.
5
Types of neurons in the enteric nervous system.肠神经系统中的神经元类型。
J Auton Nerv Syst. 2000 Jul 3;81(1-3):87-96. doi: 10.1016/s0165-1838(00)00127-2.
6
Gastrointestinal motor and myoelectric correlates of motion sickness.
Am J Physiol. 1999 Sep;277(3):G642-52. doi: 10.1152/ajpgi.1999.277.3.G642.
7
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Dig Dis Sci. 1996 Aug;41(8):1546-50. doi: 10.1007/BF02087898.
8
Characterization of vagal innervation to the rat celiac, suprarenal and mesenteric ganglia.大鼠腹腔神经节、肾上腺神经节和肠系膜神经节迷走神经支配的特征
J Auton Nerv Syst. 1993 Feb;42(2):153-69. doi: 10.1016/0165-1838(93)90046-w.
9
Pharyngeal, esophageal, and proximal gastric responses associated with vomiting.与呕吐相关的咽部、食管及近端胃部反应。
Am J Physiol. 1993 Nov;265(5 Pt 1):G963-72. doi: 10.1152/ajpgi.1993.265.5.G963.
10
Retroperistaltism and duodenogastric reflux in dogs.
Scand J Gastroenterol Suppl. 1981;67:29-32.