Hypertension in 2015: Resistant hypertension: impact and evolving treatment options.

Arterial hypertension elevates the risk of adverse renal and cardiovascular outcomes, which can be decreased by maneuvers that lower blood pressure (BP). However, a combination of multiple antihypertensive drugs at optimal doses fails to achieve BP control in up to 15% of the hypertensive population. This has led to a relentless search for novel therapeutic alternatives in order to achieve satisfactory control of BP levels. Several prominent studies published in 2015 have shed light on the risks imposed by uncontrolled or partially treated hypertension, and evaluate new therapeutic modalities designed to address the unmet needs of the treatment-resistant hypertensive individual.