Lerman Lilach O, Textor Stephen C
Division of Nephrology &Hypertension, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.
Nat Rev Nephrol. 2016 Feb;12(2):70-2. doi: 10.1038/nrneph.2015.199. Epub 2015 Dec 14.
Arterial hypertension elevates the risk of adverse renal and cardiovascular outcomes, which can be decreased by maneuvers that lower blood pressure (BP). However, a combination of multiple antihypertensive drugs at optimal doses fails to achieve BP control in up to 15% of the hypertensive population. This has led to a relentless search for novel therapeutic alternatives in order to achieve satisfactory control of BP levels. Several prominent studies published in 2015 have shed light on the risks imposed by uncontrolled or partially treated hypertension, and evaluate new therapeutic modalities designed to address the unmet needs of the treatment-resistant hypertensive individual.
动脉高血压会增加不良肾脏和心血管结局的风险，而通过降低血压（BP）的措施可以降低这种风险。然而，使用最佳剂量的多种抗高血压药物联合治疗，仍有高达15%的高血压患者无法实现血压控制。这促使人们不断寻找新的治疗方法，以实现对血压水平的满意控制。2015年发表的几项重要研究揭示了未控制或部分治疗的高血压所带来的风险，并评估了旨在满足难治性高血压患者未满足需求的新治疗模式。
