van dan Berg-Loonen P M, Dekker-Saeys A J, Meuwissen S G, Nijenhuis L E
J Rheumatol Suppl. 1977;3:57-9.
An increased frequency of HLA B27 was confirmed in a series of 118 patients with ankylosing spondylitis. This was significantly higher in patients who acquired the disease at an early age. Other deviating antigen frequencies were found to be due to linkage disequilibrium. An increased frequency of antigen BW16 was noted in B27 negative patients. In ulcerative colitis, a significantly raised incidence of A11 was found, as well as an increased frequency of B18 in Crohn's disease. The only deviating frequency from controls for blood and serum groups was in blood group Kell, which was increased in Crohn's disease.
在一组118例强直性脊柱炎患者中，HLA B27的频率增加得到了证实。在幼年发病的患者中，该频率显著更高。发现其他抗原频率的偏差是由于连锁不平衡。在B27阴性患者中，抗原BW16的频率增加。在溃疡性结肠炎中，发现A11的发病率显著升高，在克罗恩病中B18的频率增加。血液和血清组中唯一与对照组有偏差的频率是在凯尔血型，其在克罗恩病中增加。
