犬类多能干细胞：它们准备好用于临床应用了吗？
Canine Pluripotent Stem Cells: Are They Ready for Clinical Applications?
机构信息
Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario , London, ON , Canada ; Children's Health Research Institute, Lawson Health Research Institute , London, ON , Canada.
Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario , London, ON , Canada.
出版信息
Front Vet Sci. 2015 Oct 7;2:41. doi: 10.3389/fvets.2015.00041. eCollection 2015.
Abstract
The derivation of canine embryonic stem cells and generation of canine-induced pluripotent stem cells are significant achievements that have unlocked the potential for developing novel cell-based disease models, drug discovery platforms, and transplantation therapies in the dog. A progression from concept to cure in this clinically relevant companion animal will not only help our canine patients but also help advance human regenerative medicine. Nevertheless, many issues remain to be resolved before pluripotent cells can be used clinically in a safe and reproducible manner.
摘要
犬胚胎干细胞的衍生和犬诱导多能干细胞的生成是重大成就，它们为开发新型基于细胞的疾病模型、药物发现平台以及犬的移植治疗开辟了潜力。在这种临床相关的伴侣动物中，从概念到治愈的进展不仅将帮助我们的犬类患者，还有助于推进人类再生医学。然而，在多能细胞能够以安全和可重复的方式用于临床之前，仍有许多问题需要解决。
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