Cuttler Jerry M, Feinendegen Ludwig E
Cuttler & Associates Inc.
Brookhaven National Laboratory, Biological, Environmental & Climate Sciences.
Dose Response. 2015 May 4;13(1). doi: 10.2203/dose-response.15-003.Cuttler. eCollection 2015 Jan-Mar.
Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from (239)PuO2 inhalation, as a prophylaxis against lung cancer.
几项关于吸入二氧化钚颗粒对狗的影响以及狗患肺癌发生率的研究表明，当累积α辐射剂量较低时会产生有益效果。对于肿瘤发生率过高和寿命缩短的情况，在约100 cGy的暴露水平存在一个阈值。这些观察结果符合辐射兴奋效应剂量反应模型的预期，与线性无阈假说的预测相矛盾。这些研究建议探讨采用低剂量α辐射（如吸入（239）PuO2产生的辐射）作为预防肺癌手段的可能性。
