Roy Sayon, Amin Shruti, Roy Sumon
Departments of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA, United States.
Departments of Medicine and Ophthalmology, Boston University School of Medicine, Boston, MA, United States.
Exp Eye Res. 2016 Jan;142:71-5. doi: 10.1016/j.exer.2015.04.004.
In response to injury, reparative processes are triggered to restore the damaged tissue; however, such processes are not always successful in rebuilding the original state. The formation of fibrous connective tissue is known as fibrosis, a hallmark of the reparative process. For fibrosis to be successful, delicately balanced cellular events involving cell proliferation, cell migration, and extracellular matrix (ECM) remodeling must occur in a highly orchestrated manner. While successful repair may result in a fibrous scar, this often restores structural stability and functionality to the injured tissue. However, depending on the functionality of the injured tissue, a fibrotic scar can have a devastating effect. For example, in the retina, fibrotic scarring may compromise vision and ultimately lead to blindness. In this review, we discuss some of the retinal fibrotic complications and highlight mechanisms underlying the development of retinal fibrosis in diabetic retinopathy.
作为对损伤的反应，修复过程被触发以恢复受损组织；然而，这些过程在重建原始状态方面并不总是成功的。纤维结缔组织的形成被称为纤维化，这是修复过程的一个标志。为了使纤维化成功，涉及细胞增殖、细胞迁移和细胞外基质（ECM）重塑的微妙平衡的细胞事件必须以高度协调的方式发生。虽然成功的修复可能会形成纤维瘢痕，但这通常会恢复受损组织的结构稳定性和功能。然而，根据受损组织的功能，纤维化瘢痕可能会产生毁灭性影响。例如，在视网膜中，纤维化瘢痕可能会损害视力并最终导致失明。在本综述中，我们讨论了一些视网膜纤维化并发症，并强调了糖尿病性视网膜病变中视网膜纤维化发展的潜在机制。
