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高剂量维生素C对新加坡癌症患者的影响:九例病例

Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases.

作者信息

Raymond Yuen Chuen Fong, Glenda Chong Sze Ling, Meng Lim Kah

机构信息

Hosanna Clinic, Singapore.

Gene Oasis Research and Innovation, Singapore

出版信息

Integr Cancer Ther. 2016 Jun;15(2):197-204. doi: 10.1177/1534735415622010. Epub 2015 Dec 17.

Abstract

UNLABELLED

Introduction Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document administration of supportive vitamin C therapy for cancer patients in Singapore.

METHODS

The clinical response of 9 cancer patients of differing stages to the regular administration of large doses (25-100 g/d) of intravenous vitamin C (IVC; ascorbic acid) is outlined. Tumor pathology and patient health were verified by doctors who do not practice vitamin C treatment.

RESULTS

Cases suggesting survival beyond prognosis, improvement in quality of life, safe coadministration with and improved tolerance of conventional therapy, and deterioration in clinical condition following withdrawal of vitamin C therapy are documented clinically. Some patients experience the Jarisch-Herxheimer reaction-the release of endotoxin from microorganism death resulting in pimples, fever, and body odor-for a few hours after the therapy, but these are resolved quickly with no lasting effects.

CONCLUSION

Randomized trials of IVC therapy are recommended because it has minimal side effects and has shown promising results.

摘要

未标注

引言 静脉注射大剂量维生素C疗法在自然疗法和综合肿瘤学中被广泛应用;然而,新加坡从未进行过一项回顾其疗效的研究。本文旨在记录新加坡癌症患者接受支持性维生素C疗法的情况。

方法

概述了9例不同分期癌症患者定期静脉注射大剂量(25 - 100克/天)维生素C(IVC;抗坏血酸)后的临床反应。肿瘤病理和患者健康状况由不从事维生素C治疗的医生进行核实。

结果

临床上记录了一些病例,显示患者存活时间超过预期、生活质量改善、与传统疗法安全联合使用且耐受性提高,以及停用维生素C疗法后临床状况恶化。一些患者在治疗后数小时会出现雅里希 - 赫克斯海默反应——微生物死亡释放内毒素导致丘疹、发热和体味,但这些反应很快就会消退,没有持久影响。

结论

建议对IVC疗法进行随机试验,因为它副作用极小且已显示出有前景的结果。

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本文引用的文献

1
Intravenous Vitamin C and Cancer: A Systematic Review.
Integr Cancer Ther. 2014 Jul;13(4):280-300. doi: 10.1177/1534735414534463. Epub 2014 May 26.
2
Systemic skin whitening/lightening agents: what is the evidence?
Indian J Dermatol Venereol Leprol. 2013 Nov-Dec;79(6):842-6. doi: 10.4103/0378-6323.120752.
3
The effects of high concentrations of vitamin C on cancer cells.
Nutrients. 2013 Sep 9;5(9):3496-505. doi: 10.3390/nu5093496.
4
Ascorbic acid and its pro-oxidant activity as a therapy for tumours of oral cavity -- a systematic review.
Arch Oral Biol. 2013 Jun;58(6):563-74. doi: 10.1016/j.archoralbio.2013.01.016. Epub 2013 Mar 8.
5
Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8.
J Biol Chem. 2013 Mar 29;288(13):9092-101. doi: 10.1074/jbc.M112.436790. Epub 2013 Feb 8.
8
Cancer is a preventable disease that requires major lifestyle changes.
Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15.
9
Preventing cancer through tobacco and infection control: how many lives can we save in the next 10 years?
Eur J Cancer Prev. 2008 Apr;17(2):153-61. doi: 10.1097/CEJ.0b013e3282b6fda8.
10
Cancer statistics, 2007.
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66. doi: 10.3322/canjclin.57.1.43.

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