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癌症是一种可预防的疾病,需要对生活方式进行重大改变。

Cancer is a preventable disease that requires major lifestyle changes.

作者信息

Anand Preetha, Kunnumakkara Ajaikumar B, Sundaram Chitra, Harikumar Kuzhuvelil B, Tharakan Sheeja T, Lai Oiki S, Sung Bokyung, Aggarwal Bharat B

机构信息

Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

出版信息

Pharm Res. 2008 Sep;25(9):2097-116. doi: 10.1007/s11095-008-9661-9. Epub 2008 Jul 15.

Abstract

This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5-10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90-95% have their roots in the environment and lifestyle. The lifestyle factors include cigarette smoking, diet (fried foods, red meat), alcohol, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The evidence indicates that of all cancer-related deaths, almost 25-30% are due to tobacco, as many as 30-35% are linked to diet, about 15-20% are due to infections, and the remaining percentage are due to other factors like radiation, stress, physical activity, environmental pollutants etc. Therefore, cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups. In this review, we present evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it. In addition, we provide evidence that cancer is a preventable disease that requires major lifestyle changes.

摘要

今年,预计超过100万美国人以及全球超过1000万人将被诊断出患有癌症,这是一种普遍认为可预防的疾病。所有癌症病例中只有5%-10%可归因于基因缺陷,而其余90%-95%都源于环境和生活方式。生活方式因素包括吸烟、饮食(油炸食品、红肉)、饮酒、日晒、环境污染物、感染、压力、肥胖和缺乏身体活动。有证据表明,在所有与癌症相关的死亡中,近25%-30%是由烟草导致的,多达30%-35%与饮食有关,约15%-20%是由感染引起的,其余百分比则归因于其他因素,如辐射、压力、身体活动、环境污染物等。因此,预防癌症需要戒烟、增加水果和蔬菜的摄入量、适度饮酒、限制热量摄入、进行锻炼、避免直接暴露在阳光下、尽量少吃肉、食用全谷物、接种疫苗以及定期体检。在本综述中,我们提供证据表明炎症是导致癌症的因素与预防癌症的因素之间的联系。此外,我们还提供证据表明癌症是一种可预防的疾病,需要对生活方式进行重大改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f68/2515569/99b99587b2e8/11095_2008_9661_Fig1_HTML.jpg

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