Samorinha Catarina, Severo Milton, Alves Elisabete, Machado Helena, Figueiredo Bárbara, Silva Susana
EPIUnit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-600 Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
EPIUnit, Institute of Public Health, University of Porto, Rua das Taipas 135, 4050-600 Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
Reprod Biomed Online. 2016 Feb;32(2):247-56. doi: 10.1016/j.rbmo.2015.11.018. Epub 2015 Nov 30.
Between 2011 and 2012, 213 heterosexual couples undergoing fertility treatments in a Portuguese public fertility centre were systematically recruited to assess factors associated with willingness to donate embryos for research. Data were collected by questionnaire. Most couples (87.3%; 95% CI 82.1 to 91.5) were willing to donate embryos for research, citing benefits for science, health and infertile patients. Almost all couples (94.3%; 95% CI 89.8 to 96.7) reached consensus about the decision. Willingness to donate was more frequent in women younger than 36 years (adjusted OR 3.06; 95% CI 1.23 to 7.61) and who considered embryo research to be very important (adjusted OR: 6.32; 95% CI 1.85 to 21.64), and in Catholic men (adjusted OR 4.16; 95% CI 1.53 to 11.30). Those unwilling to donate reported conceptualizing embryos as children or living beings and a lack of information or fears about embryo research. Men with higher levels of trait anxiety (adjusted OR 0.90; 95% CI 0.84 to 0.96) were less frequently willing to donate. Future research on embryo disposition decision-making should include the assessment of gender differences and psychosocial factors. Ethically robust policies and accurate information about the results of human embryo research are required.
2011年至2012年期间，在葡萄牙一家公共生育中心接受生育治疗的213对异性恋夫妇被系统招募，以评估与捐赠胚胎用于研究的意愿相关的因素。通过问卷调查收集数据。大多数夫妇（87.3%；95%置信区间82.1%至91.5%）愿意捐赠胚胎用于研究，理由是对科学、健康和不孕患者有益。几乎所有夫妇（94.3%；95%置信区间89.8%至96.7%）在该决定上达成了共识。36岁以下的女性（调整后的比值比为3.06；95%置信区间1.23至7.61）、认为胚胎研究非常重要的女性（调整后的比值比为6.32；95%置信区间1.85至21.64）以及天主教男性（调整后的比值比为4.16；95%置信区间1.53至11.30）更常愿意捐赠。那些不愿意捐赠的人表示将胚胎概念化为儿童或生物，并且缺乏关于胚胎研究的信息或对此感到恐惧。特质焦虑水平较高的男性（调整后的比值比为0.90；95%置信区间0.84至0.96）愿意捐赠的频率较低。未来关于胚胎处置决策的研究应包括对性别差异和社会心理因素的评估。需要符合伦理规范的政策以及关于人类胚胎研究结果的准确信息。
